Evidence map›Paper›PMID 39164781›Full record

ArticleSkeletal muscle2024

Muscle degeneration in aging Drosophila flies: the role of mechanical stress.

Maria Chechenova, Lilla McLendon, Bracey Dallas, Hannah Stratton, Kaveh Kiani, Erik Gerberich, Alesia Alekseyenko, Natasya Tamba, SooBin An, Lizzet Castillo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Maria ChechenovaDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Lilla McLendonDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Bracey DallasDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Hannah StrattonDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Kaveh KianiDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Erik GerberichDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Alesia AlekseyenkoDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Natasya TambaDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
SooBin AnDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Lizzet CastilloDepartment of Biology, University of New Mexico, Albuquerque, NM, USA.
Emily CzajkowskiDepartment of Biology, University of New Mexico, Albuquerque, NM, USA.
Christina TalleyDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA.
Austin BrownDepartment of Mathematics, Kennesaw State University, Kennesaw, GA, USA.
Anton L BryantsevDepartment of Molecular and Cellular Biology, Kennesaw State University, 105 Marietta Dr., NW, Room 4004, MD 1201, Kennesaw, GA, 30144, USA. abryants@kennesaw.edu.

Funding

Identifying Critical Molecular Targets to Suppress Age-Related Muscle Fiber LossR03AG048496 · NIA · UNIVERSITY OF NEW MEXICO · PI BRYANTSEV, ANTON · 2014 to 2015
$141k
NIA NIH HHS R03 AG048496NIH HHS R03 AG048496
6 · The paper itself

Abstract

Muscle wasting is a universal hallmark of aging which is displayed by a wide range of organisms, although the causes and mechanisms of this phenomenon are not fully understood. We used Drosophila to characterize the phenomenon of spontaneous muscle fiber degeneration (SMFD) during aging. We found that SMFD occurs across diverse types of somatic muscles, progresses with chronological age, and positively correlates with functional muscle decline. Data from vital dyes and morphological markers imply that degenerative fibers most likely die by necrosis. Mechanistically, SMFD is driven by the damage resulting from muscle contractions, and the nervous system may play a significant role in this process. Our quantitative model of SMFD assessment can be useful in identifying and validating novel genetic factors that influence aging-related muscle wasting.

Indexed as

AgingStress, MechanicalAnimalsDrosophila melanogasterMuscle ContractionMuscle Fibers, SkeletalMuscular AtrophyAgingDegenerationDrosophilaMechanical stressMuscleMuscle fiberNecrosisSarcopenia

Identifiers

PMID39164781
PMCPMC11334408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.