ArticleParticle and fibre toxicology2024
Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients.
Article in Particle and fibre toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06965023 (Microplastics and Nanoplastics), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health impacts of micro- and nanoplastics in humans: systematic review of in vivo evidence.Environmental health : a global access science source · 2026Pooled it
- Nanoplastic Particle Exposure Induces Toxicity and Amplifies Cellular Stress in THP-1 Macrophages: Insights on Molecular Pathways and Circulating Proteome Interaction.Journal of biochemical and molecular toxicology · 2026Article
- Micro- and Nanoplastics in Cardiovascular Toxicology: Human Tissue Detection, Clinical Phenotypes, and Adverse Outcome Signals.Cardiovascular toxicology · 2026Review
- Micro- and Nanoplastics as Emerging Cardiovascular Risk Factors: A Systematic Review.Journal of xenobiotics · 2026Review
- Environmental Exposure to Micro- and Nanoplastics: Linking Cardiovascular Disease and Cancer Through Shared Biological Pathways-A Critical Review.Antioxidants (Basel, Switzerland) · 2026Review
- Micro-nanoplastics in Cardiovascular Disease: A Critical Update from Environmental Exposure to Clinical Implications.Cardiovascular toxicology · 2026Review
- Micro-and Nano-Plastic Exposure as an Emerging Risk for Atherosclerotic Cardiovascular Disease.Current atherosclerosis reports · 2026Review
- Circulating Microplastics in Acute Ischemic Stroke: Feasibility, Variability, and Exploratory Comparisons with Healthy Individuals.Clinical neuroradiology · 2026Article
- Environmental Micro(nano)plastic Exposure and Associated Human Health Risks: A Comprehensive Review.Toxics · 2026Review
- Marine microplastic concentration and associations with stroke and chronic disease prevalence.NPJ cardiovascular health · 2026Article
- Article
- Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways.Particle and fibre toxicology · 2026Review
- Harmful Effects of Microplastics and Nanoplastics in Human Body Systems: A Systematic Review.Diseases (Basel, Switzerland) · 2026Review
- Orthodontic derived microplastics impact macrophage differentiation and homeostasis.Progress in orthodontics · 2026Article
- From the Gut to the Brain: Microplastic-Associated Neurovascular Dysfunction and Implications for Stroke Risk.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Review
- Microplastic exposure elicits sex-specific atherosclerosis development in lean low-density lipoprotein receptor-deficient mice.Environment international · 2025Article
- Microplastics and child health: A scoping review of prenatal and early-life exposure routes and potential health risks.Toxicology reports · 2025Review
- Microplastics and Cardiovascular Disease: Should Clinicians Be Paying Attention?Current cardiology reports · 2025Review
- The toxicological impact of PET-MPs exposure on atherosclerosis: insights from network toxicology, molecular docking, and machine learning.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundMicroplastics, widely present in the environment, are implicated in disease pathogenesis through oxidative stress and immune modulation. Prevailing research, primarily based on animal and cell studies, falls short in elucidating microplastics' impact on human cardiovascular health. This cross-sectional study detected blood microplastic concentrations in patients presenting with chest pain using pyrolysis-gas chromatography/mass spectrometry and evaluating inflammatory and immune markers through flow cytometry, to explore the potential effects of microplastic on acute coronary syndrome.
resultsThe study included 101 participants, comprising 19 controls and 82 acute coronary syndrome cases. Notably, acute coronary syndrome patients exhibited elevated microplastic concentrations, with those suffering from acute myocardial infarction presenting higher loads compared to those with unstable angina. Furthermore, patients at intermediate to high risk of coronary artery disease displayed significantly higher microplastic accumulations than their low-risk counterparts. A significant relationship was observed between increased microplastic levels and enhanced IL-6 and IL-12p70 contents, alongside elevated B lymphocyte and natural killer cell counts.
conclusionThese results suggest an association between microplastics and both vascular pathology complexity and immunoinflammatory response in acute coronary syndrome, underscoring the critical need for targeted research to delineate the mechanisms of this association. HIGHLIGHTS: 1 Blood microplastic levels escalate from angiographic patency, to angina patients, peaking in myocardial infarction patients. 2 Microplastics in acute coronary syndrome patients are predominantly PE, followed by PVC, PS, and PP. 3 Microplastics may induce immune cell-associated inflammatory responses in acute coronary syndrome patients.
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