Evidence map›Paper›PMID 39164664›Full record

ArticleBMC microbiology2024

Solid waste dumpsite leachate and contiguous surface water contain multidrug-resistant ESBL-producing Escherichia coli carrying Extended Spectrum β-Lactamase (ESBL) genes.

Abimbola O Adekanmbi, Akeem G Rabiu, Daniel J Ajose, Olabisi C Akinlabi, Kehinde A Bolarinwa, Esther P Farinu, Adedolapo V Olaposi, Adedoyin O Adeyemi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abimbola O AdekanmbiEnvironmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Oyo State, Nigeria. ao.adekanmbi@ui.edu.ng.ORCID http://orcid.org/0000-0002-2871-1002
Akeem G RabiuDepartment of Microbiology, Federal University of Health Sciences, Ila-Orangun, Osun State, Nigeria. akeem.rabiu@fuhsi.edu.ng.ORCID http://orcid.org/0000-0001-6232-7680
Daniel J AjoseAntimicrobial Resistance and Phage Biocontrol Research Group (AREPHABREG), Department of Microbiology, School of Biological Sciences, Faculty of Natural and Agricultural Sciences, North-West University, Private Mail Bag X2046, Mmabatho, 2735, South Africa. ajosedj@yahoo.com.
Olabisi C AkinlabiDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Oyo State, Nigeria.ORCID http://orcid.org/0000-0001-8510-7189
Kehinde A BolarinwaDepartment of Education (Biology unit), Distance Learning Institute, University of Lagos, Akoka, Lagos State, Nigeria.
Esther P FarinuDepartment of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria.
Adedolapo V OlaposiEnvironmental Microbiology and Biotechnology Laboratory, Department of Microbiology, University of Ibadan, Ibadan, Oyo State, Nigeria.ORCID http://orcid.org/0000-0002-5958-662X
Adedoyin O AdeyemiThe School of Bioscience, University of Birmingham, Birmingham, UK. adedoyinadeyemi21@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dumpsites generate leachates containing bacteria that may carry antibiotic resistance genes, such as extended spectrum β-lactamase (ESBL). However, the contribution of dumpsite leachates in the environmental spread of ESBL genes has not been investigated in greater detail. This study aimed to quantify the impact of Ajakanga dumpsite leachate on the spread of ESBL genes through surface water. The susceptibility of Escherichia coli isolated from dumpsite leachate and the accompanying surface water to selected antibiotics was assessed by the standardized disc diffusion method. The isolates were evaluated for phenotypic ESBL production using the double disc synergy test (DDST). The detection of ESBL genes in the isolates was carried out using a primer-specific polymerase chain reaction (PCR). Escherichia coli isolates from leachate (n = 26/32) and surface water (n = 9/12) expressed ESBL phenotype. The ESBL-producing isolates showed the highest level of resistance to the 3rd generation cephalosporin antibiotics: cefotaxime (100%), cefpodoxime (97%), ceftazidime (97%), with low resistance observed to imipenem (6%) and azithromycin (3%). All the isolates were multidrug-resistant, showing resistance to three or more classes of antibiotics. All the ESBL-producing E. coli obtained carried bla

Indexed as

Anti-Bacterial Agentsbeta-LactamasesDrug Resistance, Multiple, BacterialEscherichia coliMicrobial Sensitivity TestsSolid WasteWater MicrobiologyAnti-Bacterial Agentsbeta-LactamasesSolid WasteAjakanga dumpsiteDumpsite leachateEscherichia coliExtended Spectrum β-Lactamase (ESBL)Solid wasteSurface water

Identifiers

PMID39164664
PMCPMC11334489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.