ArticleBMC pulmonary medicine2024
Elevated inflammatory burden index increases mortality in adults with chronic inflammatory airway diseases: a nationwide cohort study.
Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Inflammatory score, intrinsic capacity and the risk of new-onset chronic lung disease: a cohort study from the China Health and Retirement Longitudinal Study.Journal of thoracic disease · 2026Article
- Innovative Inflammatory Burden Index for identification of high mortality risk in patients with pulmonary embolism: a large retrospective cohort study.BMJ open respiratory research · 2026Article
- Association between inflammatory burden index combined with D-dimer and acute kidney injury in elderly patients.Frontiers in medicine · 2026Article
- Predictive Value of Inflammatory Burden Index for Sepsis in Critically Ill Patients with Extensive Burns: A Decade-Long Cohort Study.Journal of inflammation research · 2026Article
- Efficacy of pulmonary rehabilitation combined with minimal-dose adjunctive TCM (Shen Yi Capsules and Hua Chan Su) in improving postoperative outcomes for non-small cell lung cancer: a randomized controlled trial.Frontiers in medicine · 2026Article
- Elevated C-Reactive Protein-Albumin-Lymphocyte Index Is Associated With Reduced Mortality in Chronic Inflammatory Airway Diseases: A Population-Based Observational Study.Mediators of inflammation · 2026Observational
- Patterns of Pain in Middle-Aged and Older Adults in China: A Latent Class Analysis.Pain and therapy · 2025Article
- Associations of inflammatory burden index with the prevalence and mortality of asthma in adults: a population based study.Journal of thoracic disease · 2025Article
- Association between the inflammatory burden index and erectile dysfunction: a cross-sectional study based on NHANES 2001-2004.Journal of health, population, and nutrition · 2025Article
- Association between life's crucial 9 and lung health: a population-based study.BMC pulmonary medicine · 2025Article
- Inflammatory burden index as a predictor of mortality in septic patients: a retrospective study using the MIMIC-IV database.BMC infectious diseases · 2025Article
- Association and Predictive Ability between Inflammatory Burden Index and Fever Following Endobronchial Forceps Biopsy in Lung Cancer Patients.Journal of inflammation research · 2025Article
- The impact of inflammatory burden index on the prognosis in acute decompensated heart failure: evidence from a cohort study in Jiangxi, China.Frontiers in cardiovascular medicine · 2025Article
- Association and risk factors analysis of FeNO and CRP in bronchial asthma combined with obstructive sleep apnea.Frontiers in medicine · 2025Review
- Association between oxidative balance score and all-cause, CVD and respiratory-related mortality in the US older adults of asthma patients with diabetes.Frontiers in nutrition · 2024Article
- Prognostic value of the inflammatory burden index for disease-specific mortality and intensive care need in Fournier's gangrene.Therapeutic advances in urologyArticle
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6 authors.
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Abstract
objectiveThe objective of this study was to investigate the potential association between the inflammatory burden index (IBI) and the prevalence of chronic inflammatory airway diseases (CIAD), as well as mortality rates among individuals diagnosed with CIAD.
methodsParticipants were sourced from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2010. The IBI was calculated using the formula: IBI = C-reactive protein * neutrophils / lymphocytes. CIAD comprised self-reported asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). Mortality outcomes, including all-cause and respiratory disease mortality, were determined through linked data from the National Death Index (NDI) up to December 2019.
resultsA total of 27,495 adults were included. IBI was divided into quartiles, with the lowest quartile as the reference group. After adjusting for confounding variables, a positive correlation was observed between higher IBI and increased prevalence of total CIAD (OR = 1.383 [1.215-1.575]), asthma (OR = 1.267 [1.096-1.465]), chronic bronchitis (OR = 1.568 [1.263-1.946]), and COPD (OR = 1.907 [1.311-2.774]). Over a median follow-up of 12.33 [9.92-16.00] years, there were 1221 deaths from all causes and 220 deaths from respiratory disease among 4499 patients with CIAD. Following multivariate adjustments, the fourth quartile was significantly associated with increased risk of all-cause mortality (HR = 2.227 [1.714-2.893]) and respiratory disease mortality (HR = 2.748 [1.383-5.459]) compared to the first quartile of IBI in CIAD participants. Moreover, variable importance analysis using a random survival forest model demonstrated the significance of IBI in predicting mortality from both all-cause and respiratory diseases.
conclusionIBI exhibited an association with the prevalence of CIAD, with higher IBI levels correlating with elevated all-cause and respiratory disease mortality among individuals with CIAD.
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