Evidence map›Paper›PMID 39164544›Full record

ArticleActa parasitologica2024

Averrhoa carambola Leaf Extract Induces Apoptosis-Like Death with Increased ROS Generation in Leishmania donovani.

Priyanka Ghosh, Dibyapriya Roy Chowdhury, Pujayita Devgupta, Tapati Chakraborti

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In one paragraph

Article in Acta parasitologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Priyanka GhoshDepartment of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, 741235, India.
Dibyapriya Roy ChowdhuryDepartment of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, 741235, India.
Pujayita DevguptaDepartment of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, 741235, India.
Tapati ChakrabortiDepartment of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, 741235, India. tcbiochem@gmail.com.

Funding

Indian Council of Medical Research (ICMR) 6/9-7(298)/2022-ECD-II)University of Kalyani University of Kalyani
6 · The paper itself

Abstract

purposeThe parasitic disease leishmaniasis is responsible for high mortality and morbidity rates worldwide. The visceral form is the most severe form of leishmaniasis (or leishmaniosis), which is caused predominantly by Leishmania donovani. Currently, clinically recommended antileishmanial drugs are not convenient because of several medical complications and resistance issues. Phytocompounds are the best candidates in this regard. The present study aimed to evaluate the antileishmanial activity of Averrhoa carambola leaf extract.

methodsThe antipromastigote activity and cytotoxicity were assessed using the MTT assay. Morphological distortions were determined using phase contrast microscopy and scanning electron microscopy (SEM). Reactive oxygen species (ROS) production, nonprotein thiol depletion and apoptotic death in promastigotes were determined via flow cytometry. UV-visible spectroscopy and energy dispersive X-ray (EDX) spectroscopy was performed for elemental analysis. Fourier-transform infrared spectroscopy (FTIR) and liquid chromatography‒mass spectrometry (LCMS) were used to characterize the phytocomponent(s) present in the extract.

resultsThe chloroform extract of Averrhoa carambola leaf (AC

conclusionsThis study suggested that Averrhoa carambola leaf extracts are rich in some classes of biologically active phytocompounds and exhibit good antileishmanial activity.

Indexed as

Antiprotozoal AgentsApoptosisAverrhoaLeishmania donovaniPlant ExtractsPlant LeavesReactive Oxygen SpeciesAnimalsMiceAntiprotozoal AgentsPlant ExtractsReactive Oxygen SpeciesApoptosisAverrhoa carambolaLeishmania donovaniPhytometabolitesReactive oxygen species (ROS)

Identifiers

PMID39164544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.