Evidence map›Paper›PMID 39164460›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2024

Molecular characterization and frequency of human pegivirus type 1 (HPgV-1) in kidney transplant recipients from Central-West Brazil.

Fábio Gonçalves da Silva, Drielly Rodrigues Moura, Pâmela Maria de Oliveira, Tatyane de Souza Cardoso Quintão, Évelin Mota Cassemiro, Gabriel Montenegro de Campos, Anielly Sarana da Silva, Rafael Dos Santos Bezerra, Lorena Aparecida Gonçalves de Noronha, Walter Massa Ramalho and 4 more

Abstract read
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In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fábio Gonçalves da SilvaCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Drielly Rodrigues MouraCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Pâmela Maria de OliveiraCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Tatyane de Souza Cardoso QuintãoCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Évelin Mota CassemiroCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Gabriel Montenegro de CamposBlood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Anielly Sarana da SilvaBlood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rafael Dos Santos BezerraDepartment of Genetics, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Lorena Aparecida Gonçalves de NoronhaCampus of Ceilândia, University of Brasília, Federal District, Brasília, Brazil.
Walter Massa RamalhoCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Wildo Navegantes de AraújoCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Alex Leite PereiraCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil.
Svetoslav Nanev SlavovBlood Center of Ribeirão Preto, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Rodrigo HaddadCenter for Tropical Medicine, University of Brasília, Federal District, Brasília, Brazil. haddad@unb.br.ORCID http://orcid.org/0000-0003-4699-164X

Funding

Fundação de Apoio à Pesquisa do Distrito Federal 00193-00000751/2021-11Fundação de Apoio à Pesquisa do Distrito Federal 00193-00000932/2019-14
6 · The paper itself

Abstract

Human Pegivirus Type 1 (HPgV-1), a ubiquitous commensal virus, has been recently suggested as a marker of immunologic function. There is scarce data for the presence, genotypes, and molecular characteristics of HPgV-1 among kidney transplant recipients. Therefore, the objective of this study was to examine the prevalence and the molecular characteristics (cycle threshold, genotypes) of this viral infection among kidney transplant recipients from the Brasília, Federal District of Brazil. HPgV-1 RNA detection in the plasma was assessed by RT-qPCR. Positive samples were submitted to sequencing and phylogenetic analysis of the 5´-UTR portion of the viral genome. The estimated HPgV-1 prevalence among renal-transplant recipients was 20%. The performed phylogenetic inference revealed that the most frequent genotype among these patients was HPgV-1 genotype 2 (78.9%) presented by its two subgenotypes (2 A and 2B), followed by genotypes 1 and 3 (10.5% each). This study presents new data about the HPgV-1 circulation and molecular characteristics among kidney transplant recipients from the Federal District of Brazil. Further work is fundamental to examine the effect of HPgV-1 among patients with immunological suppression, including kidney transplant recipients.

Indexed as

Flaviviridae InfectionsKidney TransplantationPegivirusTransplant RecipientsAdultAgedBrazilFemaleGenome, ViralGenotypeHumansMaleMiddle AgedPhylogenyPrevalenceRNA, ViralRNA, ViralFrequencyGenotypeHPgV-1Kidney transplant recipients

Identifiers

PMID39164460
PMCPMC11711997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.