Evidence map›Paper›PMID 39164447›Full record

ArticleCommunications biology2024

Chemoarchitectural signatures of subcortical shape alterations in generalized epilepsy.

Yao Meng, Jinming Xiao, Siqi Yang, Jiao Li, Qiang Xu, Qirui Zhang, Guangming Lu, Huafu Chen, Zhiqiang Zhang, Wei Liao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yao MengThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Jinming XiaoThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Siqi YangSchool of Cybersecurity, Chengdu University of Information Technology, Chengdu, China.ORCID 0009-0008-4751-1664
Jiao LiThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Qiang XuDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.ORCID 0000-0002-7739-7515
Qirui ZhangDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.ORCID 0000-0002-3520-9336
Guangming LuDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.ORCID 0000-0003-4913-2314
Huafu ChenThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Zhiqiang ZhangDepartment of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.ORCID 0000-0002-3993-7330
Wei LiaoThe Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. weiliao.wl@gmail.com.ORCID 0000-0001-7406-7193

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82202250; 62036003
6 · The paper itself

Abstract

Genetic generalized epilepsies (GGE) exhibit widespread morphometric alterations in the subcortical structures. Subcortical structures are essential for understanding GGE pathophysiology, but their fine-grained morphological diversity has yet to be comprehensively investigated. Furthermore, the relationships between macroscale morphological disturbances and microscale molecular chemoarchitectures are unclear. High-resolution structural images were acquired from patients with GGE (n = 97) and sex- and age-matched healthy controls (HCs, n = 184). Individual measurements of surface shape features (thickness and surface area) of seven bilateral subcortical structures were quantified. The patients and HCs were then compared vertex-wise, and shape anomalies were co-located with brain neurotransmitter profiles. We found widespread morphological alterations in GGE and prominent disruptions in the thalamus, putamen, and hippocampus. Shape area dilations were observed in the bilateral ventral, medial, and right dorsal thalamus, as well as the bilateral lateral putamen. We found that the shape area deviation pattern was spatially correlated with the norepinephrine transporter and nicotinic acetylcholine (Ach) receptor (α

Indexed as

Epilepsy, GeneralizedAdolescentAdultBrainCase-Control StudiesFemaleHippocampusHumansMagnetic Resonance ImagingMalePutamenThalamusYoung Adult

Identifiers

PMID39164447
PMCPMC11335893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.