Evidence map›Paper›PMID 39164349›Full record

ArticleScientific reports2024

Effects of different conditioning regimens on HLA-mismatched microtransplantation and changes in fine immune indices in acute myeloid leukaemia.

Zheng Hanxue, Meng Zilu, Zhang Liansheng, Li Lijuan

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zheng HanxueDepartment of Hematology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, 730000, China.
Meng ZiluDepartment of Hematology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, 730000, China.
Zhang Liansheng *Department of Hematology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, 730000, China. zhanglsh@lzu.edu.cn.
Li Lijuan *Department of Hematology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, 730000, China. doctorjuan@sina.com.

Funding

the Clinical Medical Research Center of Hematological Diseases in Gansu Province 21JR7RA435the Commissioned Project of National Clinical Medicine Research Center for Hematological System Diseases 2021WWA01the National Natural Science Foundation of China 82360029the Natural Science Foundation of Science and Technology Program of Gansu Province 21JR7RA394
6 · The paper itself

Abstract

The aim of this study was to observe the effects of different conditioning regimens on fine immune indices after microtransplantation (MST) in patients with acute myeloid leukaemia (AML). This article discusses the possible immune mechanism of microtransplantation and describes a more optimized conditioning regimen. A total of 55 AML patients who received MST treatment at the Second Hospital of Lanzhou University from August 2015 to October 2023 were included in this study, and 13 AML patients who did not receive MST but directly received the maintenance therapy were included as the control group (C). The MST patients were divided into a conditioning regimen with venetoclax group (A) and a conditioning regimen without venetoclax group (B). The fine immune indices were detected by flow cytometry and cytometric bead array analysis. Changes in the immune indices before and after treatment were observed, and the progression-free survival (PFS) and overall survival (OS) of patients in the MST group were analysed. Compared with those in Group B, patients in Group A had better PFS and OS. The proportion of Treg cells and the expression level of IL-2 were increased, while TNF-α and IFN-α were decreased after MST (P < 0.05). In Group B, total T cells, CD4

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteTransplantation ConditioningAdolescentAdultAgedBridged Bicyclo Compounds, HeterocyclicFemaleHLA AntigensHumansMaleMiddle AgedSulfonamidesT-Lymphocytes, RegulatoryYoung AdultBridged Bicyclo Compounds, HeterocyclicHLA AntigensSulfonamidesvenetoclaxAcute myeloid leukaemiaFine immune indicesImmunologic mechanismImmunotherapyMicrotransplantation

Identifiers

PMID39164349
PMCPMC11335764

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.