Evidence map›Paper›PMID 39164310›Full record

ArticleScientific reports2024

Decoding myasthenia gravis: advanced diagnosis with infrared spectroscopy and machine learning.

Feride Severcan, Ipek Ozyurt, Ayca Dogan, Mete Severcan, Rafig Gurbanov, Fulya Kucukcankurt, Birsen Elibol, Irem Tiftikcioglu, Esra Gursoy, Melike Nur Yangin and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Feride SevercanDepartment of Biophysics, Faculty of Medicine, Altinbas University, Istanbul, Türkiye. feride@metu.edu.tr.
Ipek OzyurtDepartment of Biophysics, Faculty of Medicine, Altinbas University, Istanbul, Türkiye.
Ayca DoganDepartment of Physiology, Faculty of Medicine, Altinbas University, Istanbul, Türkiye.
Mete SevercanDepartment of Electrical and Electronics Engineering, Middle East Technical University, Ankara, Türkiye.
Rafig GurbanovDepartment of Bioengineering, Faculty of Engineering, Bilecik Seyh Edebali University, Bilecik, Türkiye.
Fulya KucukcankurtDepartment of Medical Biology, Faculty of Medicine, Altinbas University, Istanbul, Türkiye.
Birsen ElibolDepartment of Medical Biology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Türkiye.
Irem TiftikciogluCigli Training and Research Hospital, Neurology Clinic, Bakircay University, İzmir, Türkiye.
Esra GursoyDepartment of Neurology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Türkiye.
Melike Nur YanginBiomedical Sciences Graduate Program, Institute of Graduate Studies, Altinbas University, Istanbul, Türkiye.
Yasar ZorluTepecik Educational and Training Hospital, Neurology Department, University of Health Sciences, Izmir, Türkiye.

Funding

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu TUBITAK-1003 - 218S986Türkiye Bilimsel ve Teknolojik Araştırma Kurumu TUBITAK-1003 - 218S987Türkiye Bilimsel ve Teknolojik Araştırma Kurumu TUBITAK-1003 - 218S988
6 · The paper itself

Abstract

Myasthenia Gravis (MG) is a rare neurological disease. Although there are intensive efforts, the underlying mechanism of MG still has not been fully elucidated, and early diagnosis is still a question mark. Diagnostic paraclinical tests are also time-consuming, burden patients financially, and sometimes all test results can be negative. Therefore, rapid, cost-effective novel methods are essential for the early accurate diagnosis of MG. Here, we aimed to determine MG-induced spectral biomarkers from blood serum using infrared spectroscopy. Furthermore, infrared spectroscopy coupled with multivariate analysis methods e.g., principal component analysis (PCA), support vector machine (SVM), discriminant analysis and Neural Network Classifier were used for rapid MG diagnosis. The detailed spectral characterization studies revealed significant increases in lipid peroxidation; saturated lipid, protein, and DNA concentrations; protein phosphorylation; PO

Indexed as

BiomarkersMachine LearningMyasthenia GravisAdultAgedFemaleHumansMaleMiddle AgedPrincipal Component AnalysisSpectrophotometry, InfraredSpectroscopy, Fourier Transform InfraredSupport Vector MachineBiomarkers

Identifiers

PMID39164310
PMCPMC11336246

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.