Evidence map›Paper›PMID 39164264›Full record

ArticleBlood cancer journal2024

Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance.

Hauke Thomsen, Subhayan Chattopadhyay, Niels Weinhold, Pavel Vodicka, Ludmila Vodickova, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Börge Schmidt, Roman Hajek and 6 more

Abstract read
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In one paragraph

Article in Blood cancer journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic variants inFrontiers in endocrinology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hauke ThomsenMSB Medical School Berlin, Hochschule für Gesundheit und Medizin, Berlin, Germany.
Subhayan ChattopadhyayDivision of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Niels WeinholdDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Pavel VodickaInstitute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Ludmila VodickovaInstitute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Per HoffmannInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID 0000-0002-6573-983X
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.ORCID 0000-0002-8770-2464
Karl-Heinz JöckelInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Roman HajekDepartment of Hematooncology, University Hospital Ostrava and Faculty of Medicine, University of Ostrava, Ostrava, Czech Republic.ORCID 0000-0001-6955-6267
Göran HallmansDepartment of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Ulrika Pettersson-KymmerClinical Pharmacology, Department of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden.ORCID 0000-0002-0557-9803
Florentin SpäthDepartment of Diagnostics and Intervention, Cancer Center, Hematology, Umeå University, Umeå, Sweden.ORCID 0000-0002-0711-0830
Hartmut GoldschmidtDepartment of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-0961-0035
Kari HemminkiFaculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, Pilsen, Czech Republic.ORCID 0000-0002-2769-3316
Asta FörstiHopp Children's Cancer Center (KiTZ), Heidelberg, Germany. a.foersti@kitz-heidelberg.de.ORCID 0000-0002-9857-4728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units that collectively contribute to MGUS risk. To test this hypothesis, we used data from our previous GWAS on 992 MGUS cases and 2910 controls from three European populations. We identified 23 haplotypes that were associated with the risk of MGUS at the genome-wide significance level (p < 5 × 10

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyHaplotypesMonoclonal Gammopathy of Undetermined SignificancePolymorphism, Single NucleotideFemaleHumansMaleMultiple Myeloma

Identifiers

PMID39164264
PMCPMC11335940

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.