Evidence map›Paper›PMID 39164247›Full record

ArticleBone research2024

Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, that is not prevented by a diet high in calcium, phosphate, and lactose.

Stefanie Doms, Lieve Verlinden, Iris Janssens, Justine Vanhevel, Roy Eerlings, René Houtman, Shigeaki Kato, Chantal Mathieu, Brigitte Decallonne, Geert Carmeliet and 1 more

Abstract read
In one paragraph

Article in Bone research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefanie DomsDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8096-9310
Lieve VerlindenDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Iris JanssensDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Justine VanhevelDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Roy EerlingsDepartment of Cellular and Molecular Medicine, Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium.
René HoutmanPrecision Medicine Lab, Oss, The Netherlands.
Shigeaki KatoHealth Sciences Research Center, Iryo Sosei University, Iwaki, Fukuchima, Japan.
Chantal MathieuDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Brigitte DecallonneDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.
Geert CarmelietDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8324-4462
Annemieke VerstuyfDepartment of Chronic diseases and metabolism, Laboratory of Clinical and Experimental Endocrinology, KU Leuven, Leuven, Belgium. mieke.verstuyf@kuleuven.be.

Funding

Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G081723NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0D0120NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0D4217NKU Leuven (Katholieke Universiteit Leuven) C16/18/006
6 · The paper itself

Abstract

The vitamin D receptor (VDR) plays a critical role in the regulation of mineral and bone homeostasis. Upon binding of 1α,25-dihydroxyvitamin D

Indexed as

CalciumLactosePhosphatesReceptors, CalcitriolRicketsSignal TransductionAnimalsDietMiceMice, Inbred C57BLMice, KnockoutCalciumLactosePhosphatesReceptors, Calcitriol

Identifiers

PMID39164247
PMCPMC11335873

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.