ArticleNature communications2024
Dynamics of directional motor tuning in the primate premotor and primary motor cortices during sensorimotor learning.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Medial premotor cortex as a potential reservoir of reward expectancy signals influencing the primate frontoparietal network.Communications biology · 2026Article
- Functional Connectivity Between Human Motor and Somatosensory Areas During a Multifinger Tapping Task: A Proof-of-Concept Study.NeuroSci · 2026Article
- 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking.eLife · 2025Article
- 3D directional tuning in the orofacial sensorimotor cortex during natural feeding and drinking.bioRxiv : the preprint server for biology · 2025Article
- What can ANS signals tell us about motor learning? An implication for better assessment of cognitive contribution to motor learning.Frontiers in behavioral neuroscience · 2025Article
- ARViS: a bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset cerebral cortex.Nature communications · 2024Article
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Authors and funding
17 authors.
Funding
Abstract
Sensorimotor learning requires reorganization of neuronal activity in the premotor cortex (PM) and primary motor cortex (M1). To reveal PM- and M1-specific reorganization in a primate, we conducted calcium imaging in common marmosets while they learned a two-target reaching (pull/push) task after mastering a one-target reaching (pull) task. Throughout learning of the two-target reaching task, the dorsorostral PM (PMdr) showed peak activity earlier than the dorsocaudal PM (PMdc) and M1. During learning, the reaction time in pull trials increased and correlated strongly with the peak timing of PMdr activity. PMdr showed decreasing representation of newly introduced (push) movement, whereas PMdc and M1 maintained high representation of pull and push movements. Many task-related neurons in PMdc and M1 exhibited a strong preference to either movement direction. PMdc neurons dynamically switched their preferred direction depending on their performance in push trials in the early learning stage, whereas M1 neurons stably retained their preferred direction and high similarity of preferred direction between neighbors. These results suggest that in primate sensorimotor learning, dynamic directional motor tuning in PMdc converts the sensorimotor association formed in PMdr to the stable and specific motor representation of M1.
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