Evidence map›Paper›PMID 39164056›Full record

ArticleJournal of Korean medical science2024

Associations Between COVID-19, Delirium, and 1-Year Mortality: Exploring Influences on Delirium Incidence in COVID-19 Patients.

Yuna Jang, Hyun Jung Hur, Woojae Myung, Eung Joo Park, Hye Youn Park

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Risk Adjustment in Medical Research: A Bird's Eye View.Journal of Korean medical science · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuna Jang *Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0009-0004-2554-6728
Hyun Jung Hur *Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-2836-2578
Woojae MyungDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0001-9985-2032
Eung Joo ParkBig Data Center, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-0498-5751
Hye Youn ParkDepartment of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0002-5097-532X

Funding

The role of beta-endorphin in cutaneous inflammationF31ES027301 · NIEHS · HARVARD MEDICAL SCHOOL · PI SILKWORTH, WHITNEY · 2016 to 2017
$63k
Ministry of Health and Welfare HC20C0040NIEHS NIH HHS 27301C0040
6 · The paper itself

Abstract

backgroundThis study investigated the relationship between coronavirus disease 2019 (COVID-19), delirium, and 1-year mortality. Factors associated with delirium in COVID-19 patients were identified, along with the influence of psychotropic medications on delirium.

methodsThe study used the South Korean National Health Insurance Service database. Adult COVID-19 patients diagnosed between October 2020 and December 2021 were included, with a propensity score-matched control group. Time-dependent Cox regression assessed associations among COVID-19, delirium, and mortality. Logistic regression analyzed the impact of psychotropic medications on delirium incidence.

resultsThe study included 832,602 individuals, with 416,301 COVID-19 patients. COVID-19 (hazard ratio [HR], 3.03; 95% confidence interval [CI], 2.92-3.13) and delirium (HR, 2.33; 95% CI, 2.06-2.63) were independent risk factors for 1-year mortality. Comorbidities, insurance type, and residence were also related to mortality. Among COVID-19 patients, antipsychotic use was associated with lower delirium incidence (odds ratio [OR], 0.38; 95% CI, 0.30-0.47), while mood stabilizers (OR, 1.77; 95% CI, 1.40-2.21) and benzodiazepines (OR, 8.62; 95% CI, 7.46-9.97) were linked to higher delirium incidence.

conclusionCOVID-19 and delirium are risk factors for 1-year mortality. Some factors associated with delirium in COVID-19 patients are modifiable and can be targeted in preventive and therapeutic interventions.

Indexed as

COVID-19DeliriumSARS-CoV-2AdultAgedAged, 80 and overAntipsychotic AgentsComorbidityDatabases, FactualFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsPsychotropic DrugsAntipsychotic AgentsPsychotropic DrugsCOVID-19DeliriumMedicationsMortalityRisk Factors

Identifiers

PMID39164056
PMCPMC11333801

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.