Evidence map›Paper›PMID 39163913›Full record

ArticleBrain, behavior, and immunity2024

Higher inflammatory proteins predict future depressive symptom severity among adolescents with lower emotional clarity.

Auburn R Stephenson, Iris Ka-Yi Chat, Allyson T Bisgay, Christopher L Coe, Lyn Y Abramson, Lauren B Alloy

Abstract read
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In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Auburn R StephensonDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Iris Ka-Yi ChatDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Allyson T BisgayDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA.
Christopher L CoeDepartment of Psychology, University of WI, Madison, WI, USA.
Lyn Y AbramsonDepartment of Psychology, University of WI, Madison, WI, USA.
Lauren B AlloyDepartment of Psychology and Neuroscience, Temple University, Philadelphia, PA, USA. Electronic address: lalloy@temple.edu.

Funding

Integrated Reward-Inflammation Model Of First Onset Of Major Depression In Adolescence SupplementR01MH123473 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH, NUSSLOCK, ROBIN · 2021 to 2025
$3.8M
Depression Surge in Adolescence & Gender Differences: Biocognitive MechanismsR01MH079369 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ABRAMSON, LYN Y, ALLOY, LAUREN BERSH · 2008 to 2012
$3.4M
Risk for Adolescent Depression: Stress, Cognitive Vulnerability, & InflammationR01MH101168 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ALLOY, LAUREN BERSH · 2013 to 2017
$3.2M
The Relationships of Peripheral Inflammation and Reward-Related Brain Function with Anhedonia, Somatic Symptoms and Functional Impairment in AdolescenceF31MH132230 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI CHAT, KA-YI · 2022 to 2023
$66k
NIMH NIH HHS F31 MH132230NIMH NIH HHS R01 MH079369NIMH NIH HHS R01 MH101168NIMH NIH HHS R01 MH123473
6 · The paper itself

Abstract

backgroundA growing body of work has implicated inflammation in the pathogenesis of depression. As not all individuals with heightened levels of peripheral inflammation develop symptoms of depression, additional work is needed to identify other factors that catalyze the relationship between inflammation and depressive symptoms. Given that elevated levels of inflammatory activity can induce a variety of emotional changes, the present study examined whether emotional clarity, the trait-like ability to identify, discern, and express one's emotions, influences the strength of the association between inflammatory signaling and concurrent and prospective symptoms of depression.

methodsCommunity adolescents (N = 225, M

resultsHierarchical multiple regressions detected a significant interaction between inflammatory markers and emotional clarity on future depression severity, controlling for baseline depressive symptoms. Specifically, among adolescents with low levels of emotional clarity, higher levels of IL-6, CRP, and inflammatory composite scores were significantly associated with greater future depression severity.

conclusionsThese results indicate that low emotional clarity and high inflammatory signaling may jointly confer risk for prospective depressive symptom severity among adolescents. Therapeutic interventions that improve emotional clarity may reduce risk of depressive symptoms among adolescents with low-grade peripheral inflammation.

Indexed as

C-Reactive ProteinDepressionEmotionsInflammationInterleukin-6Tumor Necrosis Factor-alphaAdolescentBiomarkersFemaleHumansLongitudinal StudiesMaleSeverity of Illness IndexBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6Tumor Necrosis Factor-alphaAdolescenceDepressive symptomsEmotional clarityInflammation

Identifiers

PMID39163913
PMCPMC11418926

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.