Evidence map›Paper›PMID 39163686›Full record

ArticleInternational immunopharmacology2024

Dexmedetomidine directly binds to and inhibits Toll-like receptor 4.

Sophia Koutsogiannaki, Panop Limratana, Weiming Bu, Wiriya Maisat, Andrew McKinstry-Wu, Xiaohui Han, Umeharu Ohto, Roderic G Eckenhoff, Sulpicio G Soriano, Koichi Yuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International immunopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Targeting neuroinflammation and PVNMaterials today. Bio · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophia KoutsogiannakiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, USA; Department of Anaesthesia, Harvard Medical School, Boston, USA; Department of Immunology, Harvard Medical School, Boston, USA.
Panop LimratanaDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, USA; Department of Anaesthesia, Harvard Medical School, Boston, USA; Department of Immunology, Harvard Medical School, Boston, USA; Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Weiming BuDepartment of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Wiriya MaisatDepartment of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Andrew McKinstry-WuDepartment of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Xiaohui HanDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, USA.
Umeharu OhtoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Japan.
Roderic G EckenhoffDepartment of Anesthesia and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Sulpicio G SorianoDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, USA; Department of Anaesthesia, Harvard Medical School, Boston, USA.
Koichi YukiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, USA; Department of Anaesthesia, Harvard Medical School, Boston, USA; Department of Immunology, Harvard Medical School, Boston, USA. Electronic address: koichi.yuki@childrens.harvard.edu.

Funding

Personalized Anesthesia: The Role of the Locus Coeruleus in Individual Anesthetic ResponsesR35GM142712 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MCKINSTRY-WU, ANDREW RICH · 2021 to 2025
$2.2M
The impact of anesthetic selection on sepsis outcome and its mechanismR01GM118277 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI YUKI, KOICHI · 2016 to 2020
$1.8M
NIGMS NIH HHS R01 GM118277NIGMS NIH HHS R35 GM142712
6 · The paper itself

Abstract

backgroundWhile a number of anesthetics has been shown potentially associated with neurotoxicity in the developing brain, dexmedetomidine, a drug that was rather recently introduced into the perioperative setting, is considered beneficial from neurological wellbeing. However, the underlying mechanism of how dexmedetomidine affects brain health remains to be determined. Based on our recent study, we hypothesized that dexmedetomidine would directly bind to and inhibit Toll-like receptor 4 (TLR4), a critical receptor largely expressed in microglia and responsible for neurological insult.

methodsWe used TLR4 reporter assays to test if dexmedetomidine attenuates TLR4 activation. Furthermore, a direct binding of dexmedetomidine on TLR4 was tested using photoactivatable medetomidine. Lastly, the effect of dexmedetomidine on ketamine (anesthetic)-induced neurotoxicity was tested in rat pups (P7).

resultsWe showed that dexmedetomidine attenuated TLR4 activation using reporter assay (IC DISCUSSION: We proposed a novel mechanism of dexmedetomidine-mediated neuroprotection.

Indexed as

DexmedetomidineMicrogliaRats, Sprague-DawleyToll-Like Receptor 4AnimalsHEK293 CellsHumansKetamineMedetomidineNeuroprotective AgentsProtein BindingRatsDexmedetomidineKetamineMedetomidineNeuroprotective AgentsTlr4 protein, ratToll-Like Receptor 4DexmedetomidineMicrogliaToll-like receptor 4

Identifiers

PMID39163686
PMCPMC11408083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.