ArticleProceedings of the National Academy of Sciences of the United States of America2024
MICU1 and MICU2 control mitochondrial calcium signaling in the mammalian heart.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed.
- Mitochondria-associated endoplasmic reticulum membranes and calcium ion exchange: A novel direction for aging and neurodegenerative diseases.Neural regeneration research · 2026Article
- Revisiting Alzheimer's Disease Through the Somatostatin-Mitochondria Axis.Molecular neurobiology · 2026Review
- Early cardiac proteomic profiling in a long-latency doxorubicin cardiomyopathy model exhibits sexual dimorphism for cardioprotection.Journal of molecular and cellular cardiology plus · 2026Article
- Mechanistic Modeling of MCUx Gatekeeping, CaAmerican journal of physiology. Cell physiology · 2026Article
- Elevated mitochondrial CaStem cell reports · 2026Article
- DDRGK1 regulates muscle development by maintaining mitochondrial calcium homeostasis and oxidative phosphorylation via stabilizing IP3R.Molecular biology reports · 2026Article
- Inhibition of Cyclophilin D Rescues Cardiac Function and Bioenergetic Defects Caused by Neonatal Hypoxia.JACC. Basic to translational science · 2026Article
- Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism.Circulation research · 2026Article
- Calcium Signaling in Cardiac Fibroblasts: Roles in Fibrosis and Therapeutic Implications.Cardiovascular drugs and therapy · 2026Review
- Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Aberrant myocardial calcium cycling: pathogenic mechanisms and targeted therapeutics for heart failure.Frontiers in cardiovascular medicine · 2026Review
- Mitochondria: the central hub linking exercise to enhanced cardiac function.Frontiers in physiology · 2026Review
- MICU2 controls mitochondrial calcium signaling and migration in neurons during development.Cell reports · 2025Article
- Mitochondrial regulation of lactylation in sepsis-induced cardiomyopathy.Critical care (London, England) · 2025Review
- Oxidative stress and ferroptosis in diabetic cardiomyopathy: mechanistic interplay and therapeutic implications.Apoptosis : an international journal on programmed cell death · 2025Review
- Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.Circulation research · 2025Article
- Inter-Organellar CaCells · 2025Review
- Sarcoplasmic reticulum-mitochondria microdomains: hugging and kissing in the heart.American journal of physiology. Cell physiology · 2025Review
- The roles of mitochondria in global and local intracellular calcium signalling.Nature reviews. Molecular cell biology · 2025Review
- Mitochondrial calcium uniporter complex: An emerging therapeutic target for cardiovascular diseases (Review).International journal of molecular medicine · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Prottoy Hasan *Department of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.
Elena Berezhnaya *Department of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-4733-5348
Macarena Rodríguez-Prados *Department of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.
David WeaverDepartment of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.
Carmen BekeovaDepartment of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.
Benjamin Cartes-SaavedraDepartment of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-2753-5780
Erin BirchDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226.
Andreas M BeyerDepartment of Medicine, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI 53226.
Janine H SantosMechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709.ORCID 0000-0001-6384-3070
Erin L SeifertDepartment of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0002-8416-5763
John W ElrodDepartment of Cardiovascular Sciences, Aging+Cardiovascular Discovery Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140.ORCID 0000-0003-3925-2224
György HajnóczkyDepartment of Pathology and Genomic Medicine, MitoCare Center, Thomas Jefferson University, Philadelphia, PA 19107.ORCID 0000-0003-3813-2570
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9MSmall and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Walter J. Koch · 2017 to 2026
$21.0MTargeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2020 to 2024
$11.4MMolecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0MMitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3MCritical role of Mitochondrial Fission/Fusion in Regulation of Microvascular Endothelial FunctionR01HL157025 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI BEYER, ANDREAS M · 2021 to 2024
$2.1MMechanism of Chemotherapy Induced Microvascular Dysfunction in Cancer SurvivorsR01HL173549 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Andreas M Beyer · 2024 to 2026
$2.1MMitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5MFondation Leducq (Leducq Foundation) 16CVD04HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) RO1-HL142271NCI NIH HHS P30 CA010815NHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL142271NHLBI NIH HHS R01 HL157025NHLBI NIH HHS R01 HL173549NINDS NIH HHS R01 NS121379NINDS NIH HHS RF1 NS121379
Abstract
Activating Ca
Indexed as
CalciumCalcium-Binding ProteinsCalcium SignalingCation Transport ProteinsMitochondrial Membrane Transport ProteinsMyocytes, CardiacAnimalsCalcium ChannelsHumansMaleMiceMice, KnockoutMitochondria, HeartMyocardiumCalciumCalcium-Binding ProteinsCalcium ChannelsCation Transport ProteinsMICU1 protein, humanMICU1 protein, mouseMICU2 protein, humanMicu2 protein, mousemitochondrial calcium uniporterMitochondrial Membrane Transport ProteinscalciumcardiomyocyteMICU1MICU2mitochondrial calcium uniporter gating
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.