ArticleThe Journal of clinical endocrinology and metabolism2025
Circadian Alignment, Cardiometabolic Disease, and Sex-Specific Differences in Adults With Overweight/Obesity.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of artificial light at night on obesity and overweight: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Beyond respiratory control in COMISA: Towards precision phenotyping in PAP-based therapies.Sleep medicine reviews · 2026Article
- Chronotype and Atherogenic-Adiposity Indices in Adults Without Previously Diagnosed Chronic Disease: A Sex-Aware Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
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- Article
- Influence of circadian alignment and sleep timing variability on sex-specific inflammatory markers in healthy adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Home-based dim light melatonin onset assessment among adults with obesity: feasibility and procedural considerations.Sleep advances : a journal of the Sleep Research Society · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
contextCircadian disruption promotes weight gain and poor health. The extent to which sex plays a role in the relationship between the circadian timing of behaviors and health outcomes in individuals with overweight/obesity is unclear.
objectiveWe investigated the sex-specific associations between circadian alignment and cardiometabolic health markers in females and males with overweight/obesity.
methodsThirty volunteers with overweight/obesity (15 female; body mass index ≥25.1 kg/m2) underwent an evening in-laboratory assessment for dim-light melatonin onset (DLMO), body composition via dual energy x-ray absorptiometry, and a fasted blood sample. Circadian alignment was determined as the time difference between DLMO and average sleep onset over 7 days (phase angle), with participants categorized into narrow/wide phase angle groups based on median phase angle split. Due to known differences in metabolic markers between sexes, participants were subdivided based on sex into narrow and wide phase angle groups.
resultsMales in the narrow phase angle group had higher android/gynoid body fat distribution, triglycerides, and metabolic syndrome risk scores, while females had higher overall body fat percentage, glucose, and resting heart rates (all P < .04). Furthermore, a narrower phase angle in males was negatively associated with android/gynoid body fat (r = -0.53, P = .04) and negatively associated with body fat (r = -0.62, P = .01) and heart rate (r = -0.73, P < .01) in females.
conclusionCircadian disruption may not only promote a trajectory of weight gain but could also contribute to negative health consequences in a sex-dependent manner in those already with overweight/obesity. These data may have implications for clinical utility in sex-specific sleep and circadian interventions for adults with overweight/obesity.
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