Evidence map›Paper›PMID 39163107›Full record

ArticleeLife2024

FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility.

Yuki Kaneda, Haruhiko Miyata, Zoulan Xu, Keisuke Shimada, Maki Kamoshita, Tatsuya Nakagawa, Chihiro Emori, Masahito Ikawa

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. The deubiquitinase USP4 stabilizes the SCFNature communications · 2026
    Article
  3. PSMA8-Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Reciprocal Regulation Between the SCFbioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yuki KanedaResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-6300-4234
Haruhiko MiyataResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0003-4758-5803
Zoulan XuResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Keisuke ShimadaResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0003-3739-7163
Maki KamoshitaResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Tatsuya NakagawaResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.
Chihiro EmoriResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-8040-2517
Masahito IkawaResearch Institute for Microbial Diseases, Osaka University, Osaka, Japan.ORCID https://orcid.org/0000-0001-9859-6217

Funding

Targeting sperm-specific proteins during meiosis and sperm morphogenesisP01HD087157 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2017 to 2021
$6.2M
Functional analysis of novel testis-expressed secreted and transmembrane proteinsR01HD088412 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 2016 to 2026
$4.5M
Eunice Kennedy Shriver National Institute of Child Health and Human Development P01HD087157Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD088412Fusion Oriented REsearch for disruptive Science and Technology JPMJFR211FJapan Society for the Promotion of Science JP19H05750Japan Society for the Promotion of Science JP21H04753Japan Society for the Promotion of Science JP21H05033Japan Society for the Promotion of Science JP22H03214Japan Society for the Promotion of Science JP22K15030Japan Society for the Promotion of Science JP23K05831Japan Society for the Promotion of Science JP23K18328Japan Society for the Promotion of Science JP23KJ1523NICHD NIH HHS P01 HD087157NICHD NIH HHS R01 HD088412
6 · The paper itself

Abstract

Ribonucleoprotein (RNP) granules are membraneless electron-dense structures rich in RNAs and proteins, and involved in various cellular processes. Two RNP granules in male germ cells, intermitochondrial cement and the chromatoid body (CB), are associated with PIWI-interacting RNAs (piRNAs) and are required for transposon silencing and spermatogenesis. Other RNP granules in male germ cells, the reticulated body and CB remnants, are also essential for spermiogenesis. In this study, we disrupted FBXO24, a testis-enriched F-box protein, in mice and found numerous membraneless electron-dense granules accumulated in sperm flagella.

Indexed as

F-Box ProteinsInfertility, MaleMice, KnockoutSperm TailAnimalsCytoplasmic GranulesMaleMiceSpermatozoaF-Box ProteinsCRISPR/Cas9developmental biologymouseribonucleoprotein granulesspermiogenesis

Identifiers

PMID39163107
PMCPMC11335345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.