Evidence map›Paper›PMID 39162978›Full record

ArticleBiogerontology2024

Dietary nitrate maintains intestinal epithelia homeostasis in aged mice.

Xue Wang, Huan Liu, Mingwei Yue, Jinsong Wang, Chunmei Zhang, Lizheng Qin, Songlin Wang, Lei Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biogerontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xue WangSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
Huan LiuSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
Mingwei YueSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
Jinsong WangDepartment of Biochemistry and Molecular Biology, Capital Medical University School of Basic Medical Sciences, Beijing, 100069, China.
Chunmei ZhangSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
Lizheng QinSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China.
Songlin WangSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China. slwang@ccmu.edu.cn.
Lei HuSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing, 100050, China. hulei@ccmu.edu.cn.

Funding

Beijing Advanced Innovation Center for Big Data-based Precision Medicine PXM2021_014226_000026Beijing Municipal Education Commission 119207020201Beijing Municipal Government PXM2020_014226_000005Beijing Municipal Government PXM2021_014226_000020Beijing Municipal Government grant PXM2021-014226-000041Beijing Municipal Natural Science Foundation 7232071Beijing Municipal Science and Technology Commission Z181100001718208Chinese Research Unit of Tooth Development and Regeneration 2019-12M-5-031eijing Municipal Colleges and Universities High Level Talents Introduction and Cultivate Project-Beijing Great Wall Scholar Program CIT&TCD 20180332Innovation Research Team Project of Beijing Stomatological Hospital CXTD202201National Key Research and development Program 2022YFA1104401National Natural Science Foundation of China 81991504National Natural Science Foundation of China 82001067National Natural Science Foundation of China 82030031National Natural Science Foundation of China 92049201National Natural Science Foundation of China 92149301National Natural Science Foundation of China L2224038Scientific Research Common Program of Beijing Municipal Commission of Education KM202110025009State Key Laboratory of Oral Diseases Open Fund SKLOD2024OF15Young Scientist Program of Beijing Stomatological Hospital, Capital Medical University NO.YSP202205
6 · The paper itself

Abstract

The intestinal tract, which is the primary site of digestion and absorption of nutrients, is one of the most vulnerable organs during aging. Dietary nitrate, which is mainly derived from the diet and absorbed in the intestinal tract, is a key messenger that connecting oral and general health. However, whether dietary nitrate regulates intestinal tract homeostasis remains unclear. Our data revealed that the serum and salivary nitrate levels decreased during mice aging. The functional proteins of the epithelial barrier (E-cadherin, Claudin-1 and Zonula Occludens-1) in the colon tissues decreased during the aging process. Long-term nitrate supplement in drinking water restored the serum and salivary nitrate levels and increased the functional proteins expression of the colon epithelial barrier. Dietary nitrates increase the relative abundance of some intestinal probiotics, particularly those associated with the production of short-chain fatty acids, such as Blautia, Alloprevotella, Butyricicoccus, and Ruminococcaceae, while promoting the butyric acid production in the colon. Moreover, the expression of Sialin (encoded by Slc17a5), which is a nitrate transporter, increased in the colon epithelial cells by nitrate supplementation. The epithelial cell-conditional Slc17a5-knockout mutant mice (K14-cre; Slc17a5

Indexed as

AgingHomeostasisIntestinal MucosaNitratesAnimalsColonGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLMice, KnockoutNitratesAgingColon homeostasisMetaboliteMicrobiotaNitrateSialin

Identifiers

PMID39162978
PMCPMC11486781

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.