Evidence map›Paper›PMID 39162912›Full record

ArticleInternational journal of bipolar disorders2024

Home-based transcranial direct current stimulation in bipolar depression: an open-label treatment study of clinical outcomes, acceptability and adverse events.

Ali-Reza Ghazi-Noori, Rachel D Woodham, Hakimeh Rezaei, Mhd Saeed Sharif, Elvira Bramon, Philipp Ritter, Michael Bauer, Allan H Young, Cynthia H Y Fu

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bipolar disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05436613 nacompletednot on this map

Community-based Transcranial Direct Current Stimulation Treatment for Bipolar Depression

TypeinterventionalSponsorUniversity of East LondonRan2022 to 2024Enrolled44ConditionsDepression, Bipolar, Bipolar Disorder, Mood Disorders, Mental DisorderArmsTranscranial Direct Current Stimulation
NCT07556692 narecruitingnot on this mapstarted 2026, after this paper: background citation

Home-based Transcranial Direct Current Stimulation in Bipolar Depression: a Randomised, Double-blind, Placebo-controlled Trial

TypeinterventionalSponsorKing's College LondonRan2026 to 2027Enrolled212ConditionsBipolar Disorder (BD)ArmsFlow FL-100 tDCS headset
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning-an open-label study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali-Reza Ghazi-Noori *School of Psychology, University of East London, Arthur Edwards Building, Water Lane, London, E15 4LZ, UK.
Rachel D Woodham *School of Psychology, University of East London, Arthur Edwards Building, Water Lane, London, E15 4LZ, UK.
Hakimeh RezaeiSchool of Psychology, University of East London, Arthur Edwards Building, Water Lane, London, E15 4LZ, UK.
Mhd Saeed SharifSchool of Architecture, Computing and Engineering, University of East London, London, UK.
Elvira BramonDepartment of Psychiatry, University College London, London, UK.
Philipp RitterTechnische Universität Dresden, Dresden, Germany.
Michael BauerTechnische Universität Dresden, Dresden, Germany.
Allan H YoungCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Cynthia H Y FuSchool of Psychology, University of East London, Arthur Edwards Building, Water Lane, London, E15 4LZ, UK. c.fu@uel.ac.uk.

Funding

Disentangling the anatomical, functional and clinical heterogeneity of major depression, using machine learning methodsR01MH134236 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, FU, CYNTHIA · 2023 to 2024
$1.5M
Medical Research Council MR/W020238/1Milken Institute BD-0000000029NIMH NIH HHS R01 MH134236
6 · The paper itself

Abstract

backgroundCurrent treatments for bipolar depression have limited effectiveness, tolerability and acceptability. Transcranial direct current stimulation (tDCS) is a novel non-invasive brain stimulation method that has demonstrated treatment efficacy for major depressive episodes. tDCS is portable, safe, and individuals like having sessions at home. We developed a home-based protocol with real-time remote supervision. In the present study, we have examined the clinical outcomes, acceptability and feasibility of home-based tDCS treatment in bipolar depression.

resultsParticipants were 44 individuals with bipolar disorder (31 women), mean age 47.27 ± 12.89 years, in current depressive episode of at least moderate severity (mean Montgomery Asberg Depression Rating Scale (MADRS) score 24.59 ± 2.64). tDCS was provided in bilateral frontal montage, F3 anode, F4 cathode, 2 mA, for 30 min, in a 6-week trial, for total 21 sessions, a follow up visit was conducted 5 months from baseline. Participants maintained their current treatment (psychotherapy, antidepressant or mood stabilising medication) or maintained being medication-free. A research team member was present by video conference at each session. 93.2% participants (n = 41) completed the 6-week treatment and 72.7% of participants (n = 32) completed the 5 month follow up. There was a significant improvement in depressive symptoms following treatment (mean MADRS 8.77 ± 5.37) which was maintained at the 5 month follow up (mean MADRS 10.86 ± 6.90), rate of clinical response was 77.3% (MADRS improvement of 50% or greater from baseline), and rate of clinical remission was 47.7% (MADRS rating of 9 or less). Acceptability was endorsed as "very acceptable" or "quite acceptable" by all participants. No participants developed mania or hypomania.

conclusionsIn summary, home-based tDCS with real-time supervision was associated with significant clinical improvements and high acceptability in bipolar depression. Due to the open-label design, efficacy findings are preliminary.

trial registrationClinicalTrials.gov number NCT05436613 registered on 23 June 2022 https//www. CLINICALTRIALS: gov/study/NCT05436613.

Indexed as

Bipolar disorderDepressionNeuromodulationNon-invasiveTranscranial direct current stimulation

Identifiers

PMID39162912
PMCPMC11336151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.