Evidence map›Paper›PMID 39162889›Full record

SynthesisAging clinical and experimental research2024

Fish consumption, cognitive impairment and dementia: an updated dose-response meta-analysis of observational studies.

Justyna Godos, Agnieszka Micek, Walter Currenti, Carlotta Franchi, Andrea Poli, Maurizio Battino, Alberto Dolci, Cristian Ricci, Zoltan Ungvari, Giuseppe Grosso

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Aging clinical and experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Pooled it
  5. Review
  6. Article
  7. Nutrition and longevity - diet in centenarians.Journal of translational medicine · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. SEEK-VEC: Robust Latent Structure Discovery via Ensemble Topic Modeling.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Psychological Stress and Cognitive Brain Health: Policies to Reduce Dementia Risk.Policy insights from the behavioral and brain sciences · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Justyna GodosDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Agnieszka MicekStatistical Laboratory, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, 31-501, Poland.
Walter CurrentiDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Carlotta FranchiLaboratory of Pharmacoepidemiology and Human Nutrition, Department of Health Policy, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, 20156, Italy.
Andrea PoliNutrition Foundation of Italy (NFI), Milan, 20124, Italy.
Maurizio BattinoDepartment of Clinical Sciences, Università Politecnica Delle Marche, Ancona, Italy.
Alberto DolciSustainable Development Department, Bolton Food SpA, Milan, 20124, Italy.
Cristian RicciAfrica Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, 2531, South Africa.
Zoltan UngvariVascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Giuseppe GrossoDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy. giuseppe.grosso@unict.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCognitive impairment is projected to affect a preponderant proportion of the aging population. Lifelong dietary habits have been hypothesized to play a role in preventing cognitive decline. Among the most studied dietary components, fish consumptionhas been extensively studied for its potential effects on the human brain.

aimsTo perform a meta-analysis of observational studies exploring the association between fish intake and cognitive impairment/decline and all types of dementia.

methodsA systematic search of electronic databases was performed to identify observational studies providing quantitative data on fish consumption and outcomes of interest. Random effects models for meta-analyses using only extreme exposure categories, subgroup analyses, and dose-response analyses were performed to estimate cumulative risk ratios (RRs) and 95% confidence intervals (CIs).

resultsThe meta-analysis comprised 35 studies. Individuals reporting the highest vs. the lowest fish consumption were associated with a lower likelihood of cognitive impairment/decline (RR = 0.82, 95% CI: 0.75, 0.90, I

conclusionsCurrent findings suggest fish consumption is associated with a lower risk of cognitive impairment/decline in a dose-response manner, while for dementia and Alzheimer's disease there is a need for further studies to improve the strength of evidence.

Indexed as

Cognitive DysfunctionDementiaFishesObservational Studies as TopicAlzheimer DiseaseAnimalsDietHumansSeafoodAlzheimer’s diseaseCognitive statusDementiaFishMeta-analysis

Identifiers

PMID39162889
PMCPMC11335789

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.