Evidence map›Paper›PMID 39162873›Full record

ArticleArchives of microbiology2024

Mechanistic insights into antifungal potential of Alexidine dihydrochloride and hexachlorophene in Candida albicans: a drug repurposing approach.

Ayesha Ansari, Darshan Kumar, Payal Gupta, Krishna Mohan Poluri, Nishant Rai, Faud Ameen, Navin Kumar

Abstract read
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In one paragraph

Article in Archives of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ayesha AnsariDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Darshan KumarDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Payal GuptaDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Krishna Mohan PoluriDepartment of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Nishant RaiDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India.
Faud AmeenDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Navin KumarDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, 248001, Uttarakhand, India. navinkumar.bt@geu.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida albicans has been listed in the critical priority group by the WHO in 2022 depending upon its contribution in invasive candidiasis and increased resistance to conventional drugs. Drug repurposing offers an efficient, rapid, and cost-effective solution to develop alternative therapeutics against pathogenic microbes. Alexidine dihydrochloride (AXD) and hexachlorophene (HCP) are FDA approved anti-cancer and anti-septic drugs, respectively. In this study, we have shown antifungal properties of AXD and HCP against the wild type (reference strain) and clinical isolates of C. albicans. The minimum inhibitory concentrations (MIC

Indexed as

Antifungal AgentsBiofilmsCandida albicansDrug RepositioningMicrobial Sensitivity TestsAmidinesBiguanidesCandidiasisErgosterolHumansHyphaeVirulencealexidineAmidinesAntifungal AgentsBiguanidesErgosterolAlexidine dihydrochlorideBiofilmC. AlbicansECMHexachloropheneROS

Identifiers

PMID39162873

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.