Evidence map›Paper›PMID 39162858›Full record

ArticleOdontology2025

Anti-inflammatory effects of hesperidin on human gingival fibroblasts stimulated by lipopolysaccharide of Porphyromonas gingivalis in vitro.

Ryotaro Suzuki, Kousuke Maruyama, Soh Sato

Abstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryotaro SuzukiPeriodontology, Graduate School of Life Dentistry at Niigata, The Nippon Dental University, Chiyoda, Japan. ryotaro8@ngt.ndu.ac.jp.ORCID http://orcid.org/0009-0002-5393-4416
Kousuke MaruyamaDepartment of Periodontology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chou-ku, Niigata, 951-8150, Japan.
Soh SatoPeriodontology, Graduate School of Life Dentistry at Niigata, The Nippon Dental University, Chiyoda, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal disease is an inflammatory disease caused by periodontopathogenic bacteria, the inflammatory response generated against them, and host factors. Furthermore, environmental factors can lead to disease progression. Using lipopolysaccharide (LPS)-stimulated human gingival fibroblast (HGF), this study investigated the bioactivity of HGF after exposure to hesperidin (Hesp) and the anti-inflammatory activity of Hesp against early periodontitis. HGF were cultured in Dulbecco's modified Eagle's medium containing 15% fetal bovine serum. They were exposed to LPS for 6 h, followed by Hesp (1, 10, 30, and 50 µM) exposure for 4 h. Cell proliferation was evaluated using reduction staining with alamerBlue

Indexed as

Anti-Inflammatory AgentsFibroblastsGingivaHesperidinLipopolysaccharidesPorphyromonas gingivalisCell ProliferationCells, CulturedHumansInterleukin-6Interleukin-8In Vitro TechniquesToll-Like Receptor 4Anti-Inflammatory AgentsHesperidinInterleukin-6Interleukin-8LipopolysaccharidesToll-Like Receptor 4Chemical plaque controlHesperidinHuman gingival fibroblastLipopolysaccharidePeriodontitis

Identifiers

PMID39162858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.