Evidence map›Paper›PMID 39162817›Full record

ArticleArchives of dermatological research2024

Elafin level in lichen planus.

Reham William Doss, Esraa Hatem Ahmed Mohammed, Eman Hamdy Mohamed, Mona Elsayd Ahmed Abdellatif

Abstract read
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In one paragraph

Article in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Reham William DossDermatology Department, Faculty of Medicine, Beni-Suef University, Mohammed Hassan Street, Beni Suef, Beni- Suef, 62511, Egypt. reham.doss@med.bsu.edu.eg.
Esraa Hatem Ahmed MohammedDermatology Department, Faculty of Medicine, Beni-Suef University, Mohammed Hassan Street, Beni Suef, Beni- Suef, 62511, Egypt.
Eman Hamdy MohamedClinical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni- Suef, Egypt.
Mona Elsayd Ahmed AbdellatifDermatology Department, Faculty of Medicine, Beni-Suef University, Mohammed Hassan Street, Beni Suef, Beni- Suef, 62511, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lichen planus (LP) is a chronic, inflammatory, autoimmune disease that affects the skin, oral mucosa and genital mucosa. Elafin is an epithelial host-defense protein that is absent in normal skin but highly expressed in inflamed skin keratinocytes. Overexpression of Elafin has been reported in various infective, inflammatory skin disorders, such as cellulitis, psoriasis, Behçet's syndrome, and graft versus host disease. The aim of this case- control study is to map the level of Elafin in LP in order to investigate its role in the pathogenesis of LP. This study included 30 LP patients and 30 healthy controls. 10 cc blood samples were withdrawn from study participants to evaluate the serum level of Elafin using enzyme-linked immunosorbent assay (ELISA) technique. Serum Elafin level was significantly higher in LP patients as compared to healthy controls; the mean values were (32.56 vs. 5.60) in LP cases and healthy controls respectively with a statistically significant p-value < 0.001. We conclude that Elafin could be part of the inflammatory autoimmune process in LP.

Indexed as

ElafinLichen PlanusAdultCase-Control StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedSkinYoung AdultElafinPI3 protein, humanAutoimmune diseasesLichen planusPathogenesis

Identifiers

PMID39162817

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.