ArticleAbdominal radiology (New York)2025
Peripheral liver metastases are more frequently missed than central metastases in contrast-enhanced CT: insights from a 25-reader performance study.
Article in Abdominal radiology (New York), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reading, Fast and Slow: Characterizing Radiologists' Visual Search Through Abdominal CT for Detecting Hepatic Metastases.Academic radiology · 2026Article
- A Deep Learning Algorithm for Liver Metastasis Detection at Contrast-enhanced Abdominal CT in Patients with Colorectal Cancer: A Comparative Study with Radiologists.Radiology. Imaging cancer · 2026Article
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14 authors.
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Abstract
purposeSubtle liver metastases may be missed in contrast enhanced CT imaging. We determined the impact of lesion location and conspicuity on metastasis detection using data from a prior reader study.
methodsIn the prior reader study, 25 radiologists examined 40 CT exams each and circumscribed all suspected hepatic metastases. CT exams were chosen to include a total of 91 visually challenging metastases. The detectability of a metastasis was defined as the fraction of radiologists that circumscribed it. A conspicuity index was calculated for each metastasis by multiplying metastasis diameter with its contrast, defined as the difference between the average of a circular region within the metastasis and the average of the surrounding circular region of liver parenchyma. The effects of distance from liver edge and of conspicuity index on metastasis detectability were measured using multivariable linear regression.
resultsThe median metastasis was 1.4 cm from the edge (interquartile range [IQR], 0.9-2.1 cm). Its diameter was 1.2 cm (IQR, 0.9-1.8 cm), and its contrast was 38 HU (IQR, 23-68 HU). An increase of one standard deviation in conspicuity index was associated with a 6.9% increase in detectability (p = 0.008), whereas an increase of one standard deviation in distance from the liver edge was associated with a 5.5% increase in detectability (p = 0.03).
conclusionPeripheral liver metastases were missed more frequently than central liver metastases, with this effect depending on metastasis size and contrast.
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