ArticleThe American journal of gastroenterology2024
The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study.
Article in The American journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relationship of fat in the pancreas with cardiovascular disease: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- The Effects of Metabolic Bariatric Surgery on Intra-pancreatic Fat Deposition and Total Pancreas Volume: a Systematic Review and Meta-analysis.Obesity surgery · 2025Pooled it
- Intrapancreatic fat deposition shows distinct regional and compartmental associations with obesity and diabetes.iScience · 2026Article
- Role of SCAP in regulation of pancreatic homeostasis, pancreatitis, and tumorigenesis.Oncogene · 2026Article
- Intra-pancreatic fat deposition links to widespread systemic health risks: UK Biobank prospective cohort study.Insights into imaging · 2026Article
- Visceral fat metabolism score and cardiovascular-kidney-metabolic syndrome stages in all-cause and cause-specific mortality: insights from UK Biobank.Nutrition & metabolism · 2026Article
- The Fat-Pancreas Axis: A Narrative Review Unraveling the Role of Obesity in Pancreatic Diseases.Cureus · 2025Review
- Causal Relationship Between Blood Metabolites and Prostate Cancer Risk: A Two-Sample Mendelian Randomization Study.Molecular carcinogenesis · 2025Article
- Obesity and Pancreatic Diseases: From Inflammation to Oncogenesis and the Impact of Weight Loss Interventions.Nutrients · 2025Review
- Understanding the association of intrapancreatic fat deposition with adiposity and components of metabolic syndrome in children and adolescents: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Intra-Pancreatic Fat Deposition and Pancreatitis: Insights from the COSMOS Program.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- The association between pancreatic diseases and pancreatic fat content: a cross-sectional study from the UK Biobank.Frontiers in endocrinology · 2025Article
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9 authors.
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Abstract
introductionRecent associative studies have linked intrapancreatic fat deposition (IPFD) with risk of pancreatitis, but the causal relationship remains unclear.
methodsUsing Mendelian randomization, we evaluated the causal association between genetically predicted IPFD and pancreatitis. This approach used genetic variants from genomewide association studies of IPFD (n = 25,617), acute pancreatitis (n = 6,787 cases/361,641 controls), and chronic pancreatitis (n = 3,875 cases/361,641 controls).
resultsGenetically predicted IPFD was significantly associated with acute pancreatitis (odds ratio per 1-SD increase: 1.40 [95% CI: 1.12-1.76], P = 0.0032) and chronic pancreatitis (odds ratio: 1.64 [95% CI: 1.13-2.39], P = 0.0097). DISCUSSION: Our findings support a causal role of IPFD in pancreatitis, suggesting that reducing IPFD could lower the risk of pancreatitis.
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