Evidence map›Paper›PMID 39162507›Full record

ArticleMicrobiology spectrum2024

Inhibition of SARS-CoV-2 infection by

Alexander Bontempo, Alexandra Chirino, Alireza Heidari, Alexandra Lugo, Satoru Shindo, Maria R Pastore, Riccardo Madonia, Sibel A Antonson, Cristina Godoy, Frank C Nichols and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. FASEB bioAdvances · 2026
    Article
  2. Macrophage activation and invasion byJournal of oral microbiology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Alexander BontempoDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Alexandra ChirinoDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Alireza HeidariDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Alexandra LugoDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Satoru ShindoDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Maria R PastoreDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Riccardo MadoniaDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Sibel A AntonsonDepartment of Prosthodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Cristina GodoyDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Frank C NicholsDepartment of Periodontology, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA.
Jan PotempaDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA.
Mary Ellen DaveyDepartment of Microbiology, ADA Forsyth Institute, Cambridge, Massachusetts, USA.
Toshihisa KawaiDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Mark J CayabyabDepartment of Oral Science and Translational Research, Health Professions Division, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.ORCID 0000-0002-7803-8098

Funding

Novel Recombinant Streptococcus mitis as an Oral Vaccine against HIV/AIDSR01DE027249 · NIDCR · NOVA SOUTHEASTERN UNIVERSITY · PI CAYABYAB, MARK · 2017 to 2021
$3.0M
Microbial sphingolipids and suppression of host inflammation in periodontal diseaseR01DE031159 · NIDCR · UNIVERSITY OF FLORIDA · PI DAVEY, MARY ELLEN, GIBSON, FRANK C · 2021 to 2025
$2.9M
Porphyromonas gingivalis glycine lipids mediate bone loss through TLR2R01DE027642 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI NICHOLS, FRANK C · 2019 to 2022
$1.6M
P. gingivalis Effect on Periodontal Mesenchymal Stem CellR16GM150469 · NIGMS · NOVA SOUTHEASTERN UNIVERSITY · PI Alireza Heidari · 2023 to 2026
$770k
Blue Cross and Blue Shield of Florida Foundation (Florida Blue Foundation)HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01-DE027249HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01-DE031159HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM150469NIDCR NIH HHS R01 DE027249NIDCR NIH HHS R01 DE027642NIDCR NIH HHS R01 DE031159NIGMS NIH HHS R16 GM150469
6 · The paper itself

Abstract

The COVID-19 pandemic persists despite the availability of vaccines, and it is, therefore, crucial to develop new therapeutic and preventive approaches. In this study, we investigated the potential role of oral microbiome in SARS-CoV-2 infection. Using an IMPORTANCE: The oral microbiome is important in health and disease, and in this study, we addressed the potential role of the oral microbiome in COVID-19 infection. Our

Indexed as

COVID-19MicrobiotaMouthPorphyromonas gingivalisSARS-CoV-2AnimalsChlorocebus aethiopsGingipain Cysteine EndopeptidasesHumansSalivaGingipain Cysteine Endopeptidasesantiviral agentscoronavirusCOVID-19oral microbiologyoral microbiomePorphyromonas gingivalisSARS-CoV-2

Identifiers

PMID39162507
PMCPMC11448423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.