Evidence map›Paper›PMID 39162283›Full record

ArticleCurrent drug safety2025

Inhibitory Effects of Aspirin and Ibuprofen Overdose on Cholinesterase Activity:

Parisa Saberi-Hasanabadi, Hesam Dezfulynejad, Hamidreza Mohammadi

Abstract read
PubMed Publisher
In one paragraph

Article in Current drug safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Parisa Saberi-HasanabadiDepartment of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0002-9563-2099
Hesam DezfulynejadStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Hamidreza MohammadiPharmacutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.ORCID 0000-0003-3787-6367

Funding

Mazandaran University of Medical Sciences IR.MAZUMS.3539
6 · The paper itself

Abstract

backgroundIn recent years, it has been reported that long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) may have protective effects against neurodegenerative diseases by inhibiting the activity of cholinesterase enzymes. The exact biological mechanism of these protective effects is not yet known. This study aims to assess the MATERIALS AND

methodsIn this experimental study, 70 adult male mice (20-25 g) were divided randomly into 7 groups (n= 10) including a control group that received normal saline and other groups that received different dosages of aspirin and ibuprofen (100, 200, and 300 mg/kg) in the form of intraperitoneal injection. Mice were anesthetized by ether, and blood samples were taken from the heart. Ellman´s methods were used to measure cholinesterase, erythrocytes, and serum, respectively.

resultsThe activity of cholinesterase enzymes in serum and erythrocytes decreased significantly (P<0.0001) in treated groups with aspirin and ibuprofen compared to the control samples after 3 and 24 hours. However, these inhibitory effects were variable depending on the dose of the injected drugs, and they were statistically significant at higher injection doses

conclusionThe result of this study showed that non-steroidal anti-inflammatory drugs can inhibit the activity of the cholinesterase enzymes in both

Indexed as

AcetylcholinesteraseAnti-Inflammatory Agents, Non-SteroidalAspirinButyrylcholinesteraseCholinesterase InhibitorsIbuprofenAnimalsDose-Response Relationship, DrugDrug OverdoseErythrocytesMaleMiceAcetylcholinesteraseAnti-Inflammatory Agents, Non-SteroidalAspirinButyrylcholinesteraseCholinesterase InhibitorsIbuprofenAspirincholinesterase enzymeserythrocytes assessment.ibuprofenIn vitro and in vivo studiesnon-steroidal anti-inflammatory drugs

Identifiers

PMID39162283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.