Evidence map›Paper›PMID 39162105›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Metamaterial-Assisted Illumination Nanoscopy with Exceptional Axial Resolution.

Yeon Ui Lee, Shilong Li, Junxiang Zhao, Clara Posner, Jin Zhang, Zhaowei Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Metamaterial-Assisted Illumination Nanoscopy with Exceptional Axial Resolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yeon Ui LeeDepartment of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0001-8857-1251
Shilong LiDepartment of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0002-6044-4733
Junxiang ZhaoDepartment of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Clara PosnerDepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Jin ZhangDepartment of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Zhaowei LiuDepartment of Electrical and Computer Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0002-5732-8109

Funding

Gordon and Betty Moore FoundationMinistry of Education (MOE) 2021RIS-001National Research Foundation of Korea 2022R1C1C1006040
6 · The paper itself

Abstract

Recent advancements in optical metamaterials have opened new possibilities in the exciting field of super-resolution microscopies. The far-field metamaterial-assisted illumination nanoscopies (MAINs) have, very recently, enhanced the lateral resolution to one-fifteenth of the optical wavelength. However, the axial localization accuracy of fluorophores in the MAINs remains rarely explored. Here, a MAIN with a nanometer-scale axial localization accuracy is demonstrated by monitoring the distance-dependent photobleaching dynamics of the fluorophores on top of an organic hyperbolic metamaterial (OHM) substrate under a wide-field single-objective microscope. With such a regular experimental configuration, 3D imaging of various biological samples with the resolution of ≈40 nm in the lateral dimensions and ≈5 nm in the axial dimension is realized. The demonstrated imaging modality enables the resolution of the 3D morphology of nanoscopic cellular structures with a significantly simplified experimental setup.

Indexed as

bioimagingmetamaterialsnanometer‐scale axial localizationstructured illumination microscopysuper‐resolution microscopy

Identifiers

PMID39162105
PMCPMC11497044

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.