Evidence map›Paper›PMID 39161907›Full record

ArticleBioactive materials2024

An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats.

Jialu Yao, Junlang Li, Dashuai Zhu, Yuan Li, Panagiotis Tasoudis, Shuo Liu, Xuan Mei, Kristen Popowski, Thomas G Caranasos, Haipeng Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Delaying Drug Release: A Time Capsule for the Heart.JACC. Basic to translational science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jialu YaoDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Junlang LiJoint Department of Biomedical Engineering, University of North Carolina Chapel Hill and North Carolina State University, Raleigh, NC, USA.
Dashuai ZhuDepartment of Molecular Biomedical Sciences, NC State University, Raleigh, NC, USA.
Yuan LiDepartment of Molecular Biomedical Sciences, NC State University, Raleigh, NC, USA.
Panagiotis TasoudisDivision of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shuo LiuDepartment of Molecular Biomedical Sciences, NC State University, Raleigh, NC, USA.
Xuan MeiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Kristen PopowskiDepartment of Molecular Biomedical Sciences, NC State University, Raleigh, NC, USA.
Thomas G CaranasosDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Haipeng WangDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Mingzhu XuDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Tingbo JiangDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Kan ShenDepartment of Critical Care Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Hongxia LiDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Ke HuangDepartment of Molecular Biomedical Sciences, NC State University, Raleigh, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-induced cardiotoxicity with subsequent heart failure (HF) is a major cause of morbidity and mortality in cancer survivors worldwide. Chemotherapy-induced HF is exceptionally challenging as it generally manifests in patients who are typically not eligible for left ventricular device implantation or heart transplantation. To explore alternative treatment strategies for cancer survivors suffering from chemotherapy-induced HF, we developed a minimally invasive infusible cardiac stromal cell secretomes adhesive (MISA) that could be delivered locally through an endoscope-guided intrapericardial injection. To mimic the typical clinical presentation of chemotherapy-induced HF in elder patients, we established an aged rat model in which restrictive cardiomyopathy with sequential HF was induced

Indexed as

Cardiac stromal cellsChemotherapyExtracellular matrixHeart failureIntrapericardial injectionSecretomes

Identifiers

PMID39161907
PMCPMC11331816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.