Evidence map›Paper›PMID 39161350›Full record

ReviewFrontiers in bioengineering and biotechnology2024

Therapeutic application of mesenchymal stem cell-derived exosomes in skin wound healing.

Yunhan Sun, Shun Zhang, Yukai Shen, Haoyang Lu, Xincan Zhao, Xin Wang, Yongkai Wang, Taiping Wang, Bing Liu, Lan Yao and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Clinical Applications of Extracellular Vesicles: Promises and Pitfalls.International journal of molecular sciences · 2026
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yunhan Sun *School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Shun Zhang *School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yukai ShenSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Haoyang LuSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xincan ZhaoSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Xin WangSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Yongkai WangSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Taiping WangSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Bing LiuSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Lan YaoEye Hospital of Shandong First Medical University, Jinan, Shandong, China.
Jie WenSchool of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing is a complicated obstacle, especially for chronic wounds. Mesenchymal stem cell-derived exosomes may be a promising cell-free approach for treating skin wound healing. Exosomes can accelerate wound healing by attenuating inflammation, promoting angiogenesis, cell proliferation, extracellular matrix production and remodeling. However, many issues, such as off-target effects and high degradation of exosomes in wound sites need to be addressed before applying into clinical therapy. Therefore, the bioengineering technology has been introduced to modify exosomes with greater stability and specific therapeutic property. To prolong the function time and the local concentration of exosomes in the wound bed, the use of biomaterials to load exosomes emerges as a promising strategy. In this review, we summarize the biogenesis and characteristics of exosomes, the role of exosomes in wound healing, and the therapeutic applications of modified-exosomes in wound healing. The challenges and prospects of exosomes in wound healing are also discussed.

Indexed as

bioengeneeringexosoemshydrogelnanofiberskin wound healing

Identifiers

PMID39161350
PMCPMC11330766

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.