Evidence map›Paper›PMID 39161263›Full record

ArticleThe Journal of international medical research2024

Periorbital melanosis and its possible association with insulin resistance and vitamin D deficiency: A pilot case-control study.

Sara I Taha, Lamyaa Salem, Rasha Mohamad Hassan, Mahy El-Bassiouny, Marwa Hamdy, Marwa Adham El-Mohamdy

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Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Sara I TahaDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID 0000-0001-8224-8701
Lamyaa SalemDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Rasha Mohamad HassanDepartment of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mahy El-BassiounyDepartment of Dermatology, Andrology and Venereology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Marwa HamdyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Marwa Adham El-MohamdyDepartment of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the possible association of periorbital melanosis (POM) with insulin resistance (IR) and vitamin D serum levels.

methodsIn this pilot, case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) ratio, adiponectin/leptin (A/L) ratio) were compared between cases and controls.

resultsCompared with controls, POM cases had significantly higher values of HOMA-IR and TG/HDL-c ratio, and significantly lower values of A/L and vitamin D. HOMA-IR and TG/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A/L ratio were statistically significantly negatively correlated.

conclusionPOM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.

Indexed as

AdiponectinInsulin ResistanceMelanosisVitamin DVitamin D DeficiencyAdultBiomarkersCase-Control StudiesCholesterol, HDLFemaleHumansLeptinMaleMiddle AgedPilot ProjectsTriglyceridesAdiponectinBiomarkersCholesterol, HDLLeptinTriglyceridesVitamin DInsulin resistancePeriorbital melanosisSkin pigmentationVitamin D

Identifiers

PMID39161263
PMCPMC11334248

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.