Evidence map›Paper›PMID 39161220›Full record

ArticleeLife2024

Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways.

Daphne R Knudsen-Palmer, Pravrutha Raman, Farida Ettefa, Laura De Ravin, Antony M Jose

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Intraspecific variation in the duration of epigenetic inheritance.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Evidence for multiple forms of heritable RNA silencing.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Daphne R Knudsen-PalmerDepartment of Cell Biology and Molecular Genetics, Biological Sciences Graduate Program, University of Maryland, College Park, United States.ORCID https://orcid.org/0000-0001-5745-1185
Pravrutha RamanDepartment of Cell Biology and Molecular Genetics, Biological Sciences Graduate Program, University of Maryland, College Park, United States.
Farida EttefaDepartment of Cell Biology and Molecular Genetics, Biological Sciences Graduate Program, University of Maryland, College Park, United States.
Laura De RavinDepartment of Cell Biology and Molecular Genetics, Biological Sciences Graduate Program, University of Maryland, College Park, United States.
Antony M JoseDepartment of Cell Biology and Molecular Genetics, Biological Sciences Graduate Program, University of Maryland, College Park, United States.ORCID https://orcid.org/0000-0003-1405-0618

Funding

Transgenerational gene silencing by extracellular RNAR01GM124356 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2018 to 2025
$2.8M
Movement of RNA between animal cellsR01GM111457 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI JOSE, ANTONY MERLIN · 2014 to 2018
$1.4M
National Science Foundation 2120895NIGMS NIH HHS R01 GM111457NIGMS NIH HHS R01 GM124356NIH HHS R01GM111457NIH HHS R01GM124356
6 · The paper itself

Abstract

Since double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all genes are typically considered equivalent targets for such RNA interference (RNAi). Yet, loss of some regulators of RNAi in the nematode

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsRNA, Double-StrandedRNA InterferenceAnimalsRNA-Binding ProteinsCaenorhabditis elegans ProteinsNRDE-3 protein, C elegansRNA-Binding ProteinsRNA, Double-StrandedC. eleganschromosomesepigeneticsgene expressionpUG RNAregulation of gene expressionRNA interference

Identifiers

PMID39161220
PMCPMC11335349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.