Evidence map›Paper›PMID 39161141›Full record

ArticleCurrent rheumatology reviews2025

Interleukin 18 (-137G/C, -607C/A) Polymorphisms as Genetic Biomarkers of Susceptibility to Systematic Lupus Erythematosus.

Zahra Rezaieyazdi, Payman Delavar, Houshang Rafatpanah, Rashin Ganjali, Maryam Sahebari, Samira Tabaei, Habibollah Esmaeili, Mandana Khodashahi

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Article in Current rheumatology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zahra RezaieyazdiRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Payman DelavarRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Houshang RafatpanahImmunology Research Centre, Division of Inflammation and Inflammatory Diseases, Mashhad University of Medical Sciences, Mashhad, Iran.
Rashin GanjaliImmunogenetic and Cell Culture Lab, Immunology Center, Bu-Ali Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam SahebariRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Samira TabaeiDepartment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Habibollah EsmaeiliSocial Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mandana KhodashahiRheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Funding

Vice Chancellor for Research at Mashhad University of Medical Sciences 6882
6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology. Several studies have suggested that interleukin-18 (IL-18) is associated with SLE pathogenesis. The genotype distribution of IL-18 promoter polymorphisms differs among ethnic populations. The present study aimed to investigate the correlation between IL-18 polymorphisms at positions -137 and -607 in patients situated in Northeastern Iran.

methodsThis case-control study examined the prevalence of IL-18 -137C/G and -607C/A polymorphic variants among 95 SLE patients referred to the Department of Rheumatology, who were referred to the general clinics of Ghaem Hospital and Imam Reza Hospital in Mashhad, Iran, were included in the study. In addition, 100 healthy individuals were included in the control group. DNA from whole blood was extracted by the salting-out method using a commercial kit (Biogene, US). Allelic and genotypic frequencies of polymorphisms (-137G/C, -607C/A) in the IL-18 promoter gene were analyzed using a polymerase chain reaction (PCR)-based amplification refractory mutation system (ARMS) method.

resultsThe results of this study demonstrated that the frequency of SLE patients with the homozygous C/C genotype of the IL-18 promoter gene at position -137 was significantly higher than that of the homozygous G/G genotype (P < 0.001) in normal controls. Furthermore, the polymorphism analysis performed illustrated a significant association between (-137G/C) and (-607C/A) polymorphisms in the IL-18 promoter gene and SLE (P < 0.005).

conclusionThese results indicated that the 607A/A and 137C/C polymorphisms are more prevalent in SLE. Further research involving larger sample sizes from various populations is necessary to elucidate the role of these polymorphisms and the distribution of alleles in SLE patients.

Indexed as

Genetic Predisposition to DiseaseInterleukin-18Lupus Erythematosus, SystemicMiddle Eastern PeoplePolymorphism, GeneticAdultCase-Control StudiesFemaleGene FrequencyGenetic MarkersGenotypeHumansIranMaleMiddle AgedPolymerase Chain ReactionGenetic MarkersIL18 protein, humanInterleukin-18-137G/C-607C/AIL-18polymorphismproinflammatory cytokines.systematic lupus erythematosus

Identifiers

PMID39161141

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