Evidence map›Paper›PMID 39160588›Full record

ReviewBiotechnology for biofuels and bioproducts2024

Microbial conversion of ethanol to high-value products: progress and challenges.

Manman Sun, Alex Xiong Gao, Xiuxia Liu, Zhonghu Bai, Peng Wang, Rodrigo Ledesma-Amaro

Abstract readReview
In one paragraph

Review in Biotechnology for biofuels and bioproducts, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Mitochondrial localization of key NADApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Endogenous Ethanol Metabolism and Development of MASLD-MASH.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Manman Sun *Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China.
Alex Xiong Gao *Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, 999077, China.
Xiuxia LiuNational Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi, 214112, China.
Zhonghu BaiNational Engineering Research Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi, 214112, China. baizhonghu@jiangnan.edu.cn.
Peng WangKey Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China. pengwang@ipp.ac.cn.
Rodrigo Ledesma-AmaroDepartment of Bioengineering and Imperial College Centre for Synthetic Biology, Imperial College London, London, SW7 2AZ, UK. r.ledesma-amaro@imperial.ac.uk.

Funding

BBSRC BBSRC BB/T013176/1BBSRC BB/T011408/1European Research Council (ERC) DEUSBIO-949080the Fundamental Research Funds for the Central Universities JUSRP221032the Major Projects of Science and Technology of Anhui Province 202103a06020003the National Key Research and Development Program of China 2023YFC3402400
6 · The paper itself

Abstract

Industrial biotechnology heavily relies on the microbial conversion of carbohydrate substrates derived from sugar- or starch-rich crops. This dependency poses significant challenges in the face of a rising population and food scarcity. Consequently, exploring renewable, non-competing carbon sources for sustainable bioprocessing becomes increasingly important. Ethanol, a key C2 feedstock, presents a promising alternative, especially for producing acetyl-CoA derivatives. In this review, we offer an in-depth analysis of ethanol's potential as an alternative carbon source, summarizing its distinctive characteristics when utilized by microbes, microbial ethanol metabolism pathway, and microbial responses and tolerance mechanisms to ethanol stress. We provide an update on recent progress in ethanol-based biomanufacturing and ethanol biosynthesis, discuss current challenges, and outline potential research directions to guide future advancements in this field. The insights presented here could serve as valuable theoretical support for researchers and industry professionals seeking to harness ethanol's potential for the production of high-value products.

Indexed as

Acetyl-CoABiomanufacturingEthanolEthanol metabolismRenewable carbon sourceStress responseSustainability

Identifiers

PMID39160588
PMCPMC11334397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.