Evidence map›Paper›PMID 39160463›Full record

ArticleBMC cancer2024

Noninvasive prediction of BRAF V600E mutation status of pleomorphic xanthoastrocytomas with MRI morphologic features and diffusion-weighted imaging.

Jing Yan, Cuiping Guo, Hongwei Zheng, Yinhua Li, Mengjiao Duan, Chaoli Zhang, Li Cui, Xiaofei Lv, Gui Fu, Jingliang Cheng

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Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jing Yan *Department of MRI, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China.
Cuiping Guo *Department of Radiology, Children's Hospital of Hangzhou, 195 Wenhui Road, Hangzhou, Zhejiang Province, 310014, China.
Hongwei ZhengDepartment of MRI, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China.
Yinhua LiDepartment of MRI, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China.
Mengjiao DuanDepartment of MRI, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China.
Chaoli ZhangDepartment of MRI, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China.
Li CuiDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China.
Xiaofei LvDepartment of Medical Imaging, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong Province, 510060, China.
Gui FuDepartment of Medical Imaging, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, Guangzhou, Guangdong Province, 510060, China. fugui@sysucc.org.cn.
Jingliang ChengDepartment of MRI, The First Affiliated Hospital of Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, 450052, China. chengjl@zzu.edu.cn.

Funding

the Excellent Youth Talent Cultivation Program of Innovation in Health Science and Technology of Henan Province YXKC2022061the Guangdong Basic and Applied Basic Research Foundation 2019A1515011143the Key Program of Medical Science and Technique Foundation of Henan Province SBGJ202002062the National Natural Science Foundation of China 82102149
6 · The paper itself

Abstract

objectivesSeeking a noninvasive predictor for BRAF V600E mutation status of pleomorphic xanthoastrocytomas (PXAs) is essential for their prognoses and therapeutic use of BRAF inhibitors. We aimed to noninvasively diagnose BRAF V600E-mutated PXAs using MRI morphologic, DWI and clinical parameters.

methodsThe clinical findings, anatomical MRI characteristics, and diffusion parameters of 36 pathologically confirmed PXAs were retrospectively analyzed, and BRAF V600E-mutated (n = 16) and wild-type (n = 20) groups were compared. A binary logistic-regression analysis was performed, and a ROC curve was calculated to determine the independent predictors of BRAF V600E mutation status, diagnostic accuracy, and optimal cut-off value.

resultsA comparison of findings between groups showed that BRAF V600E-mutated PXAs were more frequent in children and young adults (≤ 35 years; P = 0.042) who often had histories of seizures (P = 0.004). Furthermore, BRAF V600E-mutated PXAs generally presented as solitary masses (P = 0.024), superficial locations with meningeal attachment (P < 0.001), predominantly cystic with mural nodules (P = 0.005), and had greater minimal ADC ratio (ADC

conclusionThe BRAF V600E mutation status of PXAs could be noninvasively predicted using clinical and MRI characteristics. CRITICAL RELEVANCE STATEMENT: The noninvasive diagnostic criteria for BRAF V600E-mutated PXAs could offer guidance for the administration of BRAF V600E mutation inhibitors in the future.

Indexed as

AstrocytomaBrain NeoplasmsDiffusion Magnetic Resonance ImagingMutationProto-Oncogene Proteins B-rafAdolescentAdultChildChild, PreschoolFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPrognosisRetrospective StudiesBRAF protein, humanProto-Oncogene Proteins B-rafAstrocytomaDiffusionMagnetic resonance imagingMutationProto-oncogene proteins B-raf

Identifiers

PMID39160463
PMCPMC11331820

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.