ArticleNature neuroscience2024
Distinct active zone protein machineries mediate Ca
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Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
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Who cites it
18 citing papers in PubMed.
- Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization.Nature communications · 2026Article
- Article
- The nanoscale mobility of calcium channels is driven by readily releasable synaptic vesicles to support precise neurotransmission in livebioRxiv : the preprint server for biology · 2026Article
- Munc13 serves as a molecular filter for SNARE sorting and assembly in active zone condensates.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An unexpected specialization of the active zone scaffold RIM at high release synapses.bioRxiv : the preprint server for biology · 2026Article
- Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release.bioRxiv : the preprint server for biology · 2026Article
- Dynamic structural plasticity facilitates the developmental assembly of cochlear inner hair cell ribbon synapses.Frontiers in cell and developmental biology · 2026Article
- CASKIN2 mediates PTPσ-orchestrated transsynaptic mechanisms at excitatory synapses.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophy.Nature communications · 2025Article
- Trans-synaptic molecular context of NMDA receptor nanodomains.Nature communications · 2025Article
- Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release.Nature communications · 2025Article
- A specific negatively charged sequence confers intramolecular regulation on Munc13-1 function in synaptic exocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.PLoS biology · 2025Article
- On the targeting of voltage-gated calcium channels to neurotransmitter release sites.Current opinion in neurobiology · 2024Review
- Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons.PLoS biology · 2024Article
- The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels.Cell reports · 2024Article
- Distinct SAP102 and PSD-95 Nano-organization Defines Multiple Types of Synaptic Scaffold Protein Domains at Single Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The intracellular C-terminus confers compartment-specific targeting of voltage-gated CabioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Javier Emperador-MeleroDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1364-4935
Jonathan W AndersenDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Sarah R MetzbowerDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Aaron D LevyDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-5856-8294
Poorna A DharmasriDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.
Giovanni de NolaDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Thomas A BlanpiedDepartment of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-4957-557X
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA. kaeser@hms.harvard.edu.ORCID http://orcid.org/0000-0002-1558-1958
Funding
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI Irene M. Ghobrial · 1985 to 2026
$330.6MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MDissecting the assembly of vertebrate neurotransmitter release sites-Research Supplements to Promote Diversity in Health-Related ResearchR01MH113349 · NIMH · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$6.1MMolecular Dissection of Active Zone Functions in Neurotransmitter ReleaseR01NS083898 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2014 to 2026
$5.9MInternal Dynamics of the Postsynaptic DensityR37MH080046 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI Thomas A Blanpied · 2020 to 2026
$5.0MMolecular Mechanisms for Co‐Assembly of Endocytic and Exocytic Machineries at a SynapseK99NS129959 · NINDS · HARVARD MEDICAL SCHOOL · PI EMPERADOR MELERO, JAVIER · 2023 to 2024
$226kGlutamate receptor mediated organization of synaptic nanostructureF31MH117920 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI DHARMASRI, POORNA AKALANKA · 2018 to 2021
$112kHarvard Medical School NANCI NIH HHS P30 CA006516NICHD NIH HHS P50 HD105351NIMH NIH HHS F31 MH117920NIMH NIH HHS R01 MH113349NIMH NIH HHS R37 MH080046NINDS NIH HHS K99 NS129959NINDS NIH HHS R01 NS083898U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) F31MH117920U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH113349U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R37MH080046U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K99NS129959U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS083898
Abstract
Action potentials trigger neurotransmitter release at the presynaptic active zone with spatiotemporal precision. This is supported by protein machinery that mediates synaptic vesicle priming and clustering of Ca
Indexed as
HippocampusSynapsesSynaptic VesiclesAnimalsCalcium ChannelsCaveolin 2MiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsCalcium ChannelsCav2 protein, mouseCaveolin 2Nerve Tissue ProteinsUnc13a protein, mouse
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.