Evidence map›Paper›PMID 39160351›Full record

Trial reportNature medicine2024

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial.

Carina R Oehrn, Stephanie Cernera, Lauren H Hammer, Maria Shcherbakova, Jiaang Yao, Amelia Hahn, Sarah Wang, Jill L Ostrem, Simon Little, Philip A Starr

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03582891 (Closed Loop Deep Brain Stimulation in Parkinson's Disease and Dystonia), which is not on this map. Cited by 130 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03582891 naactive not recruitingnot on this map

Closed Loop Deep Brain Stimulation in Parkinson's Disease and Dystonia (Activa RC+S)

TypeinterventionalSponsorUniversity of California, San FranciscoRan2018 to 2028Enrolled25ConditionsParkinson Disease, DystoniaArmsSummit RC+S for Motor, 8-week pilot trial of Closed-loop vs. Open-loop Stimulation, Summit RC+S for Sleep
3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  4. [Progresses on temporal interference electromagnetic stimulation for non-invasive deep brain function modulation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Carina R Oehrn *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. carina.oehrn@ucsf.edu.ORCID http://orcid.org/0000-0001-8451-7960
Stephanie Cernera *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Lauren H Hammer *Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Maria ShcherbakovaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Jiaang YaoDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7062-2508
Amelia HahnDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Sarah WangDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Jill L OstremDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.
Simon LittleDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-6249-6230
Philip A StarrDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2733-4003

Funding

NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8M
Accelerating Dissemination of Implantable Neurotechnology for Clinical ResearchU24NS113637 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BORTON, DAVID ALLENSON, DENISON, TIMOTHY · 2020 to 2024
$4.4M
Closed Loop Deep Brain Stimulation for Parkinson's DiseaseUH3NS100544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2016 to 2022
$4.1M
The motor network in Parkinson's disease: Mechanisms of therapyR01NS090913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STARR, PHILIP ANDREW · 2014 to 2023
$3.3M
Determining the circuits and signals of sleep dysfunction in Parkinson's disease through chronic intracranial recordings and closed-loop Deep Brain StimulationR01NS131405 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Simon Little · 2023 to 2026
$2.6M
Optimizing Pharmacotherapy with Noninvasive Wearable Sensors and Subscalp EEGUH3NS123066 · NINDS · MAYO CLINIC ROCHESTER · PI Benjamin H Brinkmann, Gregory A Worrell · 2025 to 2026
$1.4M
Uncovering the neurophysiology of motivation in Parkinson™s disease with implanted adaptive brain stimulationK23NS120037 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LITTLE, SIMON · 2021 to 2024
$809k
Beyond theta: analyzing oscillations across the frequency spectrum in patients with dystonia implanted with sensing-enabled pulse generatorsF32NS129627 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CERNERA, STEPHANIE LYNN · 2023 to 2023
$69k
NINDS NIH HHS F32 NS129627NINDS NIH HHS K23 NS120037NINDS NIH HHS R01 NS090913NINDS NIH HHS R01 NS131405NINDS NIH HHS R25 NS070680NINDS NIH HHS U24 NS113637NINDS NIH HHS UH3 NS100544NINDS NIH HHS UH3 NS123066U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F32NS129627U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K23NS120037U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01 NS131405-01U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R25NS070680U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) UH3NS100544
6 · The paper itself

Abstract

Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but lacks dynamic responsiveness to changing clinical and neural states. Feedback control might improve therapeutic effectiveness, but the optimal control strategy and additional benefits of 'adaptive' neurostimulation are unclear. Here we present the results of a blinded randomized cross-over pilot trial aimed at determining the neural correlates of specific motor signs in individuals with PD and the feasibility of using these signals to drive adaptive DBS. Four male patients with PD were recruited from a population undergoing DBS implantation for motor fluctuations, with each patient receiving adaptive DBS and continuous DBS. We identified stimulation-entrained gamma oscillations in the subthalamic nucleus or motor cortex as optimal markers of high versus low dopaminergic states and their associated residual motor signs in all four patients. We then demonstrated improved motor symptoms and quality of life with adaptive compared to clinically optimized standard stimulation. The results of this pilot trial highlight the promise of personalized adaptive neurostimulation in PD based on data-driven selection of neural signals. Furthermore, these findings provide the foundation for further larger clinical trials to evaluate the efficacy of personalized adaptive neurostimulation in PD and other neurological disorders. ClinicalTrials.gov registration: NCT03582891 .

Indexed as

Deep Brain StimulationFeasibility StudiesParkinson DiseaseAgedCross-Over StudiesHumansMaleMiddle AgedMotor CortexPilot ProjectsQuality of LifeSubthalamic NucleusTreatment Outcome

Identifiers

PMID39160351
PMCPMC11826929

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.