Evidence map›Paper›PMID 39160109›Full record

ReviewBMJ open2024

Landscape analysis of the Kenyan policy on the treatment and prevention of diarrheal disease among under-5 children.

Blessing Mberu, Sheillah Simiyu, Fanta D Gutema, Daniel Sewell, Phylis J Busienei, Innocent K Tumwebaze, Kelly K Baker

Registry-linked trialAbstract readReview
In one paragraph

Review in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05322655 (Statistical and Agent-based Modeling of Complex Microbial Systems), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05322655 completednot on this map

Statistical and Agent-based Modeling of Complex Microbial Systems: a Means for Understanding Enteric Disease Transmission Among Children in Urban Neighborhoods of Kenya

TypeobservationalSponsorState University of New York at BuffaloRan2021 to 2024Enrolled286ConditionsDiarrhea, Infantile, Infection Gastrointestinal, Stunting, Wasting
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Blessing MberuPopulation Dynamics and Urbanization, African Population and Health Research Center, Nairobi, Kenya.
Sheillah SimiyuPopulation Dynamics and Urbanization, African Population and Health Research Center, Nairobi, Kenya.ORCID 0000-0003-3069-8967
Fanta D GutemaDepartment of Occupational and Environmental Health, The University of Iowa College of Public Health, Iowa City, Iowa, USA.
Daniel SewellDepartment of Biostatistics, The University of Iowa College of Public Health, Iowa City, Iowa, USA.
Phylis J BusieneiPopulation Dynamics and Urbanization, African Population and Health Research Center, Nairobi, Kenya.ORCID 0000-0002-7719-7994
Innocent K TumwebazePopulation Dynamics and Urbanization, African Population and Health Research Center, Nairobi, Kenya itumwebaze@aphrc.org.ORCID 0000-0003-2364-4602
Kelly K BakerDepartment of Occupational and Environmental Health, The University of Iowa College of Public Health, Iowa City, Iowa, USA.ORCID 0000-0002-3774-2628

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Statistical and agent-based modeling of complex microbial systems: a means for understanding enteric disease transmission among children in urban neighborhoods of KenyaR01TW011795 · FIC · UNIVERSITY OF IOWA · PI BAKER, KELLY K, SEWELL, DANIEL · 2020 to 2024
$2.7M
FIC NIH HHS R01 TW011795NIEHS NIH HHS P30 ES005605
6 · The paper itself

Abstract

objectiveDiarrhoea remains a leading cause of morbidity and death among under-5 children in Kenya, despite multipronged policy and programme initiatives to increase access to treatment. This study interrogates the comprehensiveness and adequacy of Kenya's policies, frameworks and action plans for diarrheal management and prevention. The study seeks to identify policy and practice gaps that need to be filled to strengthen diarrhoea treatment and prevention among under-5 children in Kenya.

designOur study is a landscape analysis, which seeks to identify the gaps in the current Kenya diarrheal policy, frameworks and action plans. The critical questions included their comprehensiveness, the availability of elaborate treatment, management and prevention solutions, together with updatedness, building on evidence from extant literature on key pathways to infection relating to man-animal environmental interaction, which are critical in enteric infection prevention initiatives. DATA SOURCES: We conducted an internet search of databases of Government of Kenya's Ministry of Health; relevant websites/publications of international organisations and groups (Centre for Disease Control and Prevention, UNICEF and WHO) and published and grey literature (Google searches, Google Scholar and PubMed). ELIGIBILITY CRITERIA: Included are publicly available key national diarrheal policy frameworks, plans, strategies, laws, institutional frameworks and operational guidelines that inform pertinent questions on the adequacy of policy and practice and preventive policy updates and actions. Further, peer-reviewed and grey literature on diarrheal morbidity and mortality and diarrheal prevention and management are included. The analysis excluded any information that was not referenced on the internet nor obtained from the internet. DATA EXTRACTION AND SYNTHESIS: The review team extracted the key provisions of the policy guidelines guided by a checklist and questions around the adequacy of existing national policies in addressing the determinants, prevention and treatment interventions of enteric infections and diarrhoea among under-5 children in the country. The checklist covered Kenyan background and diarrhoea situation analysis, policy objectives, policy strategies and policy implementation.

resultsThe analysis identified a corpus of strategies for the management of diarrhoea at multiple levels: health facilities, communities and households. The policies highlighted advocacy, health communication and social mobilisation, as well as logistics management and prevention strategies. However, the triangulation of evidence from the policy provisions and extant literature identified critical policy gaps in diarrhoea prevention and management in Kenya, particularly the lack of focus on zoonotic pathways to enteric infection, environment-pathogen linkages and operationalisation of the roles of social determinants of health and related services. The policy documents had limited focus on rapid diagnosis, vaccine development and deployment, together with weak funding commitment towards implementation and unclear pathways to funding responsibilities.

conclusionPolicies are central to guiding programmatic actions towards effective enteric and diarrhoea prevention and management measures in Kenya. This study shows the need for policy updates to reflect pathways to enteric infections not covered in the current policy guidelines. Further, there is a need to strengthen the treatment and management of infection through rapid diagnosis, vaccine development and deployment, and strong funding commitment towards implementation together with clear funding responsibilities. Together, these will be vital in strengthening the current policy provisions and addressing other pathways to the prevention of enteric infections relating to zoonotic, environment-pathogen linkages and social determinants of health in Kenya and other low-income and middle-income countries. TRIAL REGISTRATION NUMBER: NCT05322655.

Indexed as

DiarrheaHealth PolicyChild, PreschoolHumansInfantKenyaHealth policyHealth ServicesMortalityPrimary Health CarePublic health

Identifiers

PMID39160109
PMCPMC11337661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.