Evidence map›Paper›PMID 39160070›Full record

ArticleeNeuro2024

Homeostatic Regulation of Spike Rate within Bursts in Two Distinct Preparations.

Alishah Lakhani, Carlos Gonzalez-Islas, Zahraa Sabra, Nicholas Au Yong, Peter Wenner

Erratum issuedAbstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Alishah LakhaniDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322.ORCID https://orcid.org/0000-0003-1460-0798
Carlos Gonzalez-IslasDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322.ORCID https://orcid.org/0000-0002-3785-4494
Zahraa SabraDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322.
Nicholas Au YongDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322.
Peter WennerDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322 pwenner@emory.edu.ORCID https://orcid.org/0000-0002-7072-2194

Funding

The role of intrinsic cellular excitability in homeostatic plasticity of developing circuitsR01NS065992 · NINDS · EMORY UNIVERSITY · PI WENNER, PETER A · 2010 to 2024
$4.5M
Training In Systems And Integrative Biology NeuroscienceT32NS096050 · NINDS · EMORY UNIVERSITY · PI Yoland Smith · 2016 to 2026
$3.9M
Understanding the triggers of homeostatic synaptic scalingR21NS084358 · NINDS · EMORY UNIVERSITY · PI WENNER, PETER A · 2014 to 2015
$415k
NINDS NIH HHS R01 NS065992NINDS NIH HHS R21 NS084358NINDS NIH HHS T32 NS096050
6 · The paper itself

Abstract

Homeostatic plasticity represents a set of mechanisms thought to stabilize some function of neural activity. Here, we identified the specific features of cellular or network activity that were maintained after the perturbation of GABAergic blockade in two different systems: mouse cortical neuronal cultures where GABA is inhibitory and motoneurons in the isolated embryonic chick spinal cord where GABA is excitatory (males and females combined in both systems). We conducted a comprehensive analysis of various spiking activity characteristics following GABAergic blockade. We observed significant variability in many features after blocking GABA

Indexed as

Action PotentialsHomeostasisMotor NeuronsSpinal CordAnimalsCells, CulturedCerebral CortexChick EmbryoFemaleGABA-A Receptor AntagonistsMaleMiceMice, Inbred C57BLNeuronal PlasticityNeuronsReceptors, GABA-AGABA-A Receptor AntagonistsReceptors, GABA-Achick embryocortical culturehomeostatic plasticitymultielectrode arrayspinal cord

Identifiers

PMID39160070
PMCPMC11391507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.