Evidence map›Paper›PMID 39159683›Full record

ArticleBiochimica et biophysica acta. Molecular cell research2024

The impact of alternate-day fasting on the salivary gland stem cell compartments in non-obese diabetic mice with newly established Sjögren's syndrome.

Dongfang Li, Shoko Onodera, Qing Yu, Jing Zhou

Abstract read
In one paragraph

Article in Biochimica et biophysica acta. Molecular cell research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Sjogren's Disease and Elevated Cardiovascular Risk: Mechanisms and Treatment.Journal of cardiovascular development and disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dongfang LiThe ADA Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
Shoko OnoderaThe ADA Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA; Department of Biochemistry, Tokyo Dental College, Tokyo, Japan.
Qing YuThe ADA Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
Jing ZhouThe ADA Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA. Electronic address: jzhou@forsyth.org.

Funding

Intermittent fasting restores salivary gland function in Sjögren’s syndromeR01DE030646 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI ZHOU, JING · 2021 to 2025
$2.3M
Controlling Autoimmune Inflammation and Promoting Salivary Gland Regeneration in Sjogren's SyndromeR21DE031058 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI YU, QING · 2022 to 2023
$547k
Mechanisms and Therapeutic Modulation of T Cell Autoimmune Responses in Sjogren's SyndromeR56DE023838 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI CHA, SEUNGHEE, YU, QING · 2020 to 2020
$532k
The Role of Plasmacytoid Dentdritic Cells in the Pathogenesis of Sjogren's SyndromeR03DE028033 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI ZHOU, JING · 2019 to 2020
$398k
Role of Interleukin-22 in the Salivary Gland Disorder in Autoimmune Sjögren's SyndromeR03AI142273 · NIAID · ADA FORSYTH INSTITUTE, INC. · PI YU, QING · 2019 to 2020
$199k
NIAID NIH HHS R03 AI142273NIDCR NIH HHS R01 DE030646NIDCR NIH HHS R03 DE028033NIDCR NIH HHS R21 DE031058NIDCR NIH HHS R56 DE023838
6 · The paper itself

Abstract

Intermittent fasting exerts a profound beneficial influence on a spectrum of diseases through various mechanisms including regulation of immune responses, elimination of senescent- and pathogenic cells and improvement of stem cell-based tissue regeneration in a disease- and tissue-dependent manner. Our previous study demonstrated that alternate-day fasting (ADF) led to alleviation of xerostomia and sialadenitis in non-obese diabetic (NOD) mice, a well-defined model of Sjögren's syndrome (SS). This present study delved into the previously unexplored impacts of ADF in this disease setting and revealed that ADF increases the proportion of salivary gland stem cells (SGSCs), defined as the EpCAM

Indexed as

FastingMice, Inbred NODSalivary GlandsSjogren's SyndromeStem CellsAnimalsApoptosisDisease Models, AnimalFemaleInflammasomesMiceNLR Family, Pyrin Domain-Containing 3 ProteinSubmandibular GlandInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinCellular senescenceIntermittent fastingSjӧgren's diseaseXerostomia

Identifiers

PMID39159683
PMCPMC11368138

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.