Evidence map›Paper›PMID 39159370›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Conserved 5-methyluridine tRNA modification modulates ribosome translocation.

Joshua D Jones, Monika K Franco, Rachel N Giles, Daniel E Eyler, Mehmet Tardu, Tyler J Smith, Laura R Snyder, Yury S Polikanov, Robert T Kennedy, Rachel O Niederer and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
  2. Article
  3. tRNA modifications in viral replication.The Journal of biological chemistry · 2026
    Review
  4. RNase 4 improves bottom-up modification mapping ofbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Conserved 5-methyluridine tRNA modification modulates ribosome translocation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  20. Modifications in the T arm of tRNA globally determine tRNA maturation, function, and cellular fitness.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Joshua D Jones *Department of Chemistry, University of Michigan, Ann Arbor, MI 48109.
Monika K Franco *Program in Chemical Biology, University of Michigan, Ann Arbor, MI 48109.
Rachel N GilesDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-2801-6736
Daniel E EylerDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-6425-9770
Mehmet TarduDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-1674-5958
Tyler J SmithDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.
Laura R SnyderDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.
Yury S PolikanovDepartment of Biological Sciences, University of Illinois, Chicago, IL 60607.ORCID 0000-0002-5064-0327
Robert T KennedyDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0003-2447-7471
Rachel O NiedererDepartment of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109.
Kristin S KoutmouDepartment of Chemistry, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-7763-9262

Funding

Michigan Chemistry-Biology Interface Training ProgramT32GM132046 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Emily E Scott, Wenjing Wang · 2019 to 2026
$4.1M
Mechanisms of translational controlR35GM128836 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristin S Koutmou · 2018 to 2026
$3.2M
Translational control by 5'-UTR elementsR00GM135533 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NIEDERER, RACHEL O. · 2023 to 2025
$761k
HHS | NIH (NIH) 4R00GM135533-03NIGMS NIH HHS R00 GM135533NIGMS NIH HHS R35 GM128836NIGMS NIH HHS T32 GM132046NSF (NSF) CAREER Award 2045562NSF (NSF) CHE-1904146NSF | NSF Graduate Research Fellowship Program (GRFP) GFRP
6 · The paper itself

Abstract

While the centrality of posttranscriptional modifications to RNA biology has long been acknowledged, the function of the vast majority of modified sites remains to be discovered. Illustrative of this, there is not yet a discrete biological role assigned for one of the most highly conserved modifications, 5-methyluridine at position 54 in tRNAs (m

Indexed as

Escherichia coliRibosomesRNA, TransferSaccharomyces cerevisiaeUridineProtein BiosynthesisRNA Processing, Post-TranscriptionalSaccharomyces cerevisiae ProteinstRNA MethyltransferasesRNA, TransferSaccharomyces cerevisiae ProteinstRNA MethyltransferasesUridinemodificationprotein synthesistranslationtRNA

Identifiers

PMID39159370
PMCPMC11363252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.