Evidence map›Paper›PMID 39158961›Full record

ArticleEchocardiography (Mount Kisco, N.Y.)2024

Feasibility, reproducibility, and accuracy of echocardiographic right ventricular systolic function assessments in childhood cancer survivors at risk for heart failure.

Heidi Ostler, Lin Liu, Khang Tong, Maria T Acuero, Juliana Gomez-Arostegui, Seth Degner, Sun Choo, Fraser Golding, Sanjeet Hegde, Dennis J Kuo and 1 more

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In one paragraph

Article in Echocardiography (Mount Kisco, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heidi OstlerDepartment of Pediatrics, University of California, San Diego, California, USA.ORCID 0000-0003-4038-9850
Lin LiuHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, California, USA.
Khang TongAltman Clinical and Translational Research Institute, University of California, San Diego, California, USA.
Maria T AcueroDepartment of Pediatrics, University of California, San Diego, California, USA.
Juliana Gomez-ArosteguiDepartment of Pediatrics, University of California, San Diego, California, USA.
Seth DegnerDepartment of Cardiology, Rady Children's Hospital San Diego, San Diego, California, USA.
Sun ChooDepartment of Pediatrics, University of California, San Diego, California, USA.
Fraser GoldingDepartment of Pediatrics, University of California, San Diego, California, USA.
Sanjeet HegdeDepartment of Pediatrics, University of California, San Diego, California, USA.
Dennis J KuoDepartment of Pediatrics, University of California, San Diego, California, USA.
Hari K NarayanDepartment of Pediatrics, University of California, San Diego, California, USA.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
The Clinical Relevance of Anthracycline-Related Cardiac Remodeling in Childhood Cancer SurvivorsK23HL163456 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Hari Kope Narayan · 2023 to 2026
$786k
Ada Durairaj Research GrantNCATS NIH HHS UL1 TR001442NCATS NIH HHS UL1TR001442NCI NIH HHS P30 CA023100NHLBI NIH HHS K23 HL163456NIH HHS K23 HL163456Padres Pedal the Cause/RADY PTC2020Specialized Cancer Control Support NIH/NCI P30CA023100TEAM ABBY Gives: St. Baldrick's Foundation Scholar AwardUC San Diego Moore Cancer Center
6 · The paper itself

Abstract

purposeWe sought to assess the feasibility, reproducibility, and accuracy of conventional and newer echocardiographic measures of right ventricular (RV) systolic function in adolescent and young adult childhood cancer survivors treated with anthracyclines.

methodsEchocardiography and cardiac magnetic resonance imaging (CMR) were acquired ≤60 days apart in prospectively recruited survivors and RV functional measures were quantitated by blinded observers. Repeat quantitation was performed in a subset to evaluate reproducibility. For each echocardiographic measure, Spearman correlations with CMR measures were calculated, and values in participants with CMR RV ejection fraction (RVEF) ≥48% and RVEF <48% were compared using two sample Wilcoxon rank-sum tests.

resultsAmong 58 participants, mean age was 18.2 years (range 13.1-25.2) and five participants had CMR RVEF <48%. Intra- and inter-observer coefficients of variation were 8.2%-10.1% and 10.5%-12.0% for adjusted automated strain measures, and 5.2%-8.7% and 2.7% for 3D RVEF, respectively. No echocardiographic measures were significantly correlated with CMR RVEF; only tricuspid annular plane systolic excursion was correlated with CMR RV stroke volume (r = .392, p = .003). Participants with RV dysfunction had worse automated global longitudinal strain (-20.3% vs. -23.9%, p = .007) and free wall longitudinal strain (-23.7% vs. -26.7%, p = .09).

conclusionsEchocardiographic strain and 3D RV function measurements were feasible and reproducible in at-risk childhood cancer survivors. Although not associated with CMR RVEF in this population with predominantly normal RV function, automated strain measurements were more abnormal in participants with RV dysfunction, suggesting potential clinical utility of these measures.

Indexed as

Cancer SurvivorsEchocardiographyFeasibility StudiesHeart FailureAdolescentAdultFemaleHeart VentriclesHumansMagnetic Resonance Imaging, CineMaleNeoplasmsProspective StudiesReproducibility of ResultsStroke VolumeSystoleadolescent and young adultanthracycline cardiotoxicitycardio‐oncologychildhood cancer survivorsechocardiographic strainpediatric echocardiographyright ventricular functionthree‐dimensional echocardiography

Identifiers

PMID39158961
PMCPMC11338588

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.