Evidence map›Paper›PMID 39158838›Full record

ArticleJournal of gastrointestinal cancer2024

Both Th1 and Th2 CD4 + T-Cell Lineage Infiltrations Decrease in Post-hematopoietic Stem Cell Transplantation Colon Adenoma.

Yasuo Matsubara, Yasunori Ota, Tamami Denda, Yukihisa Tanaka, Masamichi Isobe, Seiko Kato, Takaaki Konuma, Satoshi Takahashi, Yoshihiro Hirata, Hiroaki Ikematsu and 2 more

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasuo MatsubaraDepartment of Oncology and General Medicine, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan. ma-yasu@ims.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-4378-7048
Yasunori OtaDepartment of Diagnostic Pathology, Institute of Medical Science, IMSUT Hospital, University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.
Tamami DendaDepartment of Diagnostic Pathology, Institute of Medical Science, IMSUT Hospital, University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.
Yukihisa TanakaDepartment of Diagnostic Pathology, Institute of Medical Science, IMSUT Hospital, University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.
Masamichi IsobeDepartment of Hematology/Oncology, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0003-4811-8262
Seiko KatoDepartment of Hematology/Oncology, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.
Takaaki KonumaDepartment of Hematology/Oncology, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-1953-8463
Satoshi TakahashiDepartment of Hematology/Oncology, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-1076-2338
Yoshihiro HirataDepartment of Gastroenterology, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-8324-366X
Hiroaki IkematsuDepartment of Gastroenterology, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.
Keisuke BabaDepartment of Oncology and General Medicine, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0001-9215-7539
Narikazu BokuDepartment of Oncology and General Medicine, Institute of Medical Science, IMSUT Hospital, The University of Tokyo, 4-6-1 Shirokanedai, Minato-Ku, Tokyo, 108-8639, Japan.ORCID http://orcid.org/0000-0002-1438-707X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAs long-term survival improves after allogeneic hematopoietic stem cell transplantation (HSCT), the risk for secondary solid cancers, including colon cancer, also increases. However, the pathogenesis of secondary solid cancers in post-HSCT patients remains unclear. This study aimed to investigate the involvement of local immunity in colon carcinogenesis in post-HSCT patients by assessing the infiltrating T cells in colon adenomas as premalignant lesions of colon cancer in adenoma-carcinoma sequence.

methodsColon adenoma samples obtained from 19 post-HSCT patients and 57 non-HSCT participants were analyzed via immunohistochemistry. Double staining of CD4/T-bet, CD4/GATA3, and CD4/FoxP3 was performed for evaluation of helper T-cell lineages (Th1, Th2, and regulatory T cells, respectively) and CD8 staining for CD8

resultsThere were no significant between-group differences in the number of infiltrating CD4

conclusionAlthough the number of infiltrating CD4

Indexed as

AdenomaColonic NeoplasmsHematopoietic Stem Cell TransplantationAdultAgedCD4-Positive T-LymphocytesCell LineageFemaleHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedTh1 CellsTh2 CellsCD4+ helper T cellsColon adenomasHematopoietic stem cell transplantationTumor microenvironment

Identifiers

PMID39158838

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.