Evidence map›Paper›PMID 39158802›Full record

GuidelineClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS).

Cristina Mata Fernández, Ana Sebio, Javier Orcajo Rincón, Javier Martín Broto, Antonio Martín Benlloch, David Marcilla Plaza, Antonio López Pousa, Isidro Gracia Alegría, Martina Giuppi, Erica Collado Ballesteros and 3 more

Abstract readPractice Guideline
In one paragraph

Guideline in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cristina Mata FernándezPediatric and Adolescent Oncohaematology Unit, Hospital Materno-Infantil Gregorio, Marañón, Madrid, Spain. cristina.mata@salud.madrid.org.ORCID http://orcid.org/0000-0001-9922-0078
Ana SebioMedical Oncology Department, Hospital Sant Pau, Barcelona, Spain.
Javier Orcajo RincónNuclear Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Javier Martín BrotoMedical Oncology Department, Fundación Jimenez Diaz University Hospital, University Hospital General de Villalba, and Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS/FJD; UAM), Madrid, Spain.
Antonio Martín BenllochSection Spine Unit. Orthopaedic and Traumatology Department, Dr. Peset University Hospital, Valencia, Spain.
David Marcilla PlazaDepartment of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Antonio López PousaMedical Oncology Department, Hospital Sant Pau, Barcelona, Spain.
Isidro Gracia AlegríaOrthopaedic Oncology Unit, Orthoapedic and Traumatology Department, Hospital Sant Pau, Barcelona, Spain.
Martina GiuppiSarcoma patient, Madrid, Spain.
Erica Collado BallesterosRadiation Oncologist, Hospital Universitari i Politécnic La Fe , Valencia, Spain.
Daniel BernabeuChief of Musculo-skeletal Radiology Section, Radiodiagnosis Service Hospital General Universitario La Paz, Madrid, Spain.
Enrique de AlavaDepartment of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, Institute of Biomedicine of Sevilla, IBiS/Virgen del Rocio University Hospital /CSIC/University of Sevilla/CIBERONC, Seville, Spain.
Claudia Valverde MoralesMedical Oncology Department, Hospital Universitari Vall d´Hebrón, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ewing sarcoma is a small round-cell sarcoma characterized by gene fusion involving EWSR1 (or another TET family protein like FUS) and an ETS family transcription factor. The estimated incidence of this rare bone tumor, which occurs most frequently in adolescents and young adults, is 0.3 per 100,000/year. Although only 25% of patients with Ewing sarcoma are diagnosed with metastatic disease, historical series show that this is a systemic disease. Patient management requires multimodal therapies-including intensive chemotherapy-in addition to local treatments (surgery and/or radiotherapy). In the recurrent/refractory disease setting, different approaches involving systemic treatments and local therapies are also recommended as well as patient inclusion in clinical trials whenever possible. Because of the complexity of Ewing sarcoma diagnosis and treatment, it should be carried out in specialized centers and treatment plans should be designed upfront by a multidisciplinary tumor board. These guidelines provide recommendations for diagnosis, staging, and multimodal treatment of Ewing sarcoma.

Indexed as

Bone NeoplasmsSarcoma, EwingCombined Modality TherapyHumans“Ewing like” sarcomaEwing sarcomaEWSR1Malignant bone tumoursSmall round cell sarcomas

Identifiers

PMID39158802
PMCPMC11914306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.