Evidence map›Paper›PMID 39158668›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2024

Optimizing the spatial immune landscape of CD103

Guanqun Yang, Mengyu Hu, Siqi Cai, Chaozhuo Li, Liying Yang, Miaoqing Zhao, Hongbiao Jing, Ligang Xing, Xiaorong Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular oncology (Dordrecht, Netherlands), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guanqun YangShandong University Cancer Center, Shandong University, Jinan, Shandong, China.ORCID http://orcid.org/0000-0003-4536-664X
Mengyu HuDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Siqi CaiShandong University Cancer Center, Shandong University, Jinan, Shandong, China.
Chaozhuo LiDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Liying YangShandong University Cancer Center, Shandong University, Jinan, Shandong, China.
Miaoqing ZhaoDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China.
Hongbiao JingDepartment of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Science, Jinan, Shandong, China.
Ligang XingShandong University Cancer Center, Shandong University, Jinan, Shandong, China.
Xiaorong SunShandong University Cancer Center, Shandong University, Jinan, Shandong, China. xrsun@sdfmu.edu.cn.ORCID http://orcid.org/0000-0001-8520-9556

Funding

Department of Science & Technology of Shandong Province 2021CXGC011102National Natural Science Foundation of China 82071035National Natural Science Foundation of China 82172866National Natural Science Foundation of China 82373424Natural Science Foundation of Shandong Province ZR2019LZL019Natural Science Foundation of Shandong Province ZR2021LZL005Natural Science Foundation of Shandong Province ZR2022LZL001Start-up Fund of Shandong Cancer Hospital 2020PYA04
6 · The paper itself

Abstract

backgroundNeoadjuvant chemotherapy (NAC) combined with immunotherapy is increasingly used in non-small cell lung cancer (NSCLC). Tissue-resident memory T (T

methodsWe established two NSCLC cohorts including patients undergoing upfront surgery (US) and NAC followed by surgery. Beyond the unpaired comparison between the US cohort (n = 122) and NAC cohort (n = 141) with resection samples, 58 matched pre-NAC biopsy samples were available for paired comparisons. Using multiplex immunofluorescence, we characterized T

resultsThe cell densities, infiltration scores, and cancer-cell proximity scores of T

conclusionsNAC may remodel the cell density and spatial distribution of T

Indexed as

Antigens, CDCarcinoma, Non-Small-Cell LungCD8-Positive T-LymphocytesIntegrin alpha ChainsLung NeoplasmsMemory T CellsNeoadjuvant TherapyAgedFemaleHumansMaleMiddle AgedTumor Microenvironmentalpha E integrinsAntigens, CDIntegrin alpha ChainsNeoadjuvant chemotherapyNon-small cell lung cancerSpatial distributionTissue-resident memory T cellTumor immunology

Identifiers

PMID39158668
PMCPMC12973950

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.