Evidence map›Paper›PMID 39158567›Full record

Observational studyJournal of the American Heart Association2024

Natural Course of Electrocardiographic Features in Arrhythmogenic Right Ventricular Cardiomyopathy and Their Relation to Ventricular Arrhythmic Events.

Anneli Svensson, Henrik Kjaerulf Jensen, Machteld J Boonstra, Marianne Tétreault-Langlois, Pia Dahlberg, Henning Bundgaard, Alex Hørby Christensen, Rebecca T Rylance, Jesper H Svendsen, Julia Cadrin-Tourigny and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anneli SvenssonDepartment of Cardiology Linköping University Hospital Linköping Sweden.ORCID 0000-0001-8404-0541
Henrik Kjaerulf JensenDepartment of Cardiology Aarhus University Hospital Aarhus Denmark.ORCID 0000-0003-1802-4302
Machteld J BoonstraDivision of Heart and Lungs, Department of Cardiology University Medical Center Utrecht, Utrecht University, Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart' (ERN GUARDHEART; Utrecht the Netherlands.ORCID 0000-0001-7550-0489
Marianne Tétreault-LangloisDepartment of Medicine Montreal Heart Institute, University of Montreal Canada.
Pia DahlbergDepartment of Cardiology, Department of Molecular and Clinical Medicine Institute of Medicine, Sahlgrenska Academy Gothenburg Sweden.ORCID 0000-0003-3344-1796
Henning BundgaardUnit for Inherited Cardiac Diseases, the Heart Center The National University Hospital, Rigshospitalet Copenhagen Denmark.ORCID 0000-0002-0563-7049
Alex Hørby ChristensenDepartment of Cardiology Copenhagen University Hospital Herlev-Gentofte Herlev Denmark.
Rebecca T RylanceDepartment of Cardiology, Clinical Sciences Lund University Lund Sweden.ORCID 0000-0002-5921-3786
Jesper H SvendsenDepartment of Clinical Medicine, Faculty of Health and Medical Science University of Copenhagen Denmark.ORCID 0000-0001-8466-8515
Julia Cadrin-TourignyDepartment of Medicine Montreal Heart Institute, University of Montreal Canada.ORCID 0000-0002-7489-8744
Anneline S J M Te RieleDivision of Heart and Lungs, Department of Cardiology University Medical Center Utrecht, Utrecht University, Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart: ERN GUARD-Heart' (ERN GUARDHEART; Utrecht the Netherlands.ORCID 0000-0002-4694-4790
Pyotr G PlatonovDepartment of Cardiology, Clinical Sciences Lund University Lund Sweden.ORCID 0000-0002-5592-8717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectrocardiographic abnormalities are common in arrhythmogenic right ventricular cardiomyopathy and are included in the 2010 Task Force Criteria. Their time course, however, remains uncertain. In this retrospective observational study, we aimed to assess the long-term evolution of electrocardiographic characteristics and their relation to ventricular arrhythmias. METHODS AND

resultsThree hundred fifty-three patients with arrhythmogenic right ventricular cardiomyopathy as per the 2010 Task Force Criteria with 6871 automatically processed 12-lead digital ECGs were included. The relationship between the electrocardiographic parameters and the risk of ventricular arrhythmias was assessed at 10 years from the first ECG. Electrocardiographic parameters were compared between the first contact ECG, the ECG at diagnosis, and the most recent ECG. Median time between the first and the latest ECG was 6 [interquartile range, 1-14] years. Reductions of QRS voltage, R- and T-wave amplitudes between the first, diagnostic, and the latest ECGs were observed across precordial and extremity leads. Mean QRS duration increased from 96 to 102 ms (

conclusionsDepolarization and repolarization parameters evolved over time in patients with arrhythmogenic right ventricular cardiomyopathy, supporting the progressive nature of arrhythmogenic right ventricular cardiomyopathy. Electrocardiographic abnormalities may be detected before diagnosis and might, although not fulfilling the 2010 Task Force Criteria, be markers of early disease. T-wave inversion in leads V

Indexed as

Arrhythmogenic Right Ventricular DysplasiaDisease ProgressionElectrocardiographyTachycardia, VentricularAction PotentialsAdultFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk FactorsTime Factorsarrhythmogenic right ventricular cardiomyopathyelectrocardiographylongitudinal follow‐upnatural courseprognosisventricular arrhythmia

Identifiers

PMID39158567
PMCPMC11963941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.