Evidence map›Paper›PMID 39158542›Full record

ArticleJournal of the American Heart Association2024

Relative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.

Hamza Adel Salim, Omar Hamam, Goksu Parilday, Rawan A Moustafa, Samir Ghandour, Moustafa Rutgers, Muhanned Sharara, Andrew Cho, Ishan Mazumdar, Mahla Radmard and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Hypoperfusion intensity ratio is associated with follow-up infarct volume in medium vessel occlusions: A multicenter multinational study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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  13. Perfusion imaging parameters predict long-term clinical outcome in isolated posterior cerebral artery occlusion stroke patients.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
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  20. Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hamza Adel SalimJohns Hopkins University Baltimore MD USA.ORCID 0000-0002-5208-8425
Omar HamamHarvard Medical School Boston MA USA.ORCID 0000-0002-9102-8994
Goksu ParildayAnkara University Faculty of Medicine Ankara Turkey.ORCID 0009-0005-6822-1461
Rawan A MoustafaRutgers University School Sciences New Brunswick NJ USA.
Samir GhandourHarvard Medical School Boston MA USA.ORCID 0000-0001-6419-4447
Moustafa RutgersRutgers University School of Arts and Sciences New Brunswick NJ USA.ORCID 0009-0002-8288-2272
Muhanned ShararaMedical Collage of Georgia at Augusta University Augusta GA USA.ORCID 0000-0002-2840-5646
Andrew ChoJohns Hopkins University School of Medicine Baltimore MD USA.ORCID 0000-0001-9109-2294
Ishan MazumdarJohns Hopkins University School of Medicine Baltimore MD USA.
Mahla RadmardTehran University of Medical Sciences Tehran Iran.ORCID 0000-0001-6039-3772
Christopher ShinLahey Hospital and Medical Center Burlington MA USA.
Daniel MontesUniversity of Colorado Anschutz Medical Campus Aurora CA USA.ORCID 0000-0002-5933-9397
Ajay MalhotraYale School of Medicine New Haven CT USA.ORCID 0000-0001-9223-6640
Javier M RomeroMassachusetts General Hospital Boston MA USA.ORCID 0000-0001-5749-3000
Vivek YedavalliJohns Hopkins University Baltimore MD USA.ORCID 0000-0002-2450-4014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn acute ischemic stroke (AIS), collateral status (CS) is an important predictor of favorable outcomes in patients with AIS. Among quantitative cerebral perfusion parameters, relative cerebral blood flow (rCBF) is considered an accurate perfusion-based indicator of CS. This study investigated the relationship between admission laboratory values, baseline characteristics, and CS as assessed by rCBF in patients with AIS-large vessel occlusion. METHODS AND

resultsIn this retrospective multicenter study, consecutive patients presenting with AIS secondary to anterior circulation large vessel occlusion who underwent pretreatment computed tomography perfusion were included. The computed tomography perfusion data processed by RAPID (IschemaView, Menlo Park, CA) generated the rCBF. Binary logistic regression models assessed the relationship between patients' baseline characteristics, admission laboratory values, and poor CS. The primary outcome measure was the presence of poor CS, which was defined as rCBF <38% at a lesion size ≥27 mL. Between January 2017 and September 2022, there were 221 consecutive patients with AIS-large vessel occlusion included in our study (mean age 67.0±15.8 years, 119 men [53.8%]). Logistic regression showed that male sex (odds ratio [OR], 2.98 [1.59-5.59];

conclusionsHigher stroke severity on admission with National Institutes of Health Stroke Scale score ≥12, systolic blood pressure <140, chronic kidney disease, and male sex are statistically significantly associated with poor CS in patients with AIS due to anterior circulation large vessel occlusion as defined by rCBF <38%.

Indexed as

Cerebrovascular CirculationCollateral CirculationIschemic StrokeAgedAged, 80 and overCerebral AngiographyComputed Tomography AngiographyFemaleHumansMaleMiddle AgedPerfusion ImagingRetrospective Studiesacute ischemic strokeanterior circulationcollateral statuslarge vessel occlusionrelative cerebral blood flow

Identifiers

PMID39158542
PMCPMC11963935

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.