ArticleDeutsches Arzteblatt international2024
Baseline MRI Examination in the NAKO Health Study—Findings on Feasibility, Participation and Dropout Rates, Comfort, and Image Quality.
Article in Deutsches Arzteblatt international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- VERIDAH: solving enumeration anomaly-aware vertebra labeling across imaging sequences.European radiology · 2026Article
- Breaking the norm: population-scale deviations of brain structure in depression and anxiety.Molecular psychiatry · 2026Article
- Pooled two-cohort MRI body composition phenotyping with open-source deep learning.Communications medicine · 2026Article
- Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort.Scientific reports · 2026Article
- Neurovascular compression of the left rostral ventrolateral medulla is not associated with arterial hypertension in a population-based MRI study in Germany.Neuroradiology · 2026Article
- Prediction of cognitive test scores: a comparison of brain structure, health, demographic, and cognitive data across adulthood.GeroScience · 2026Article
- Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function.Kidney international · 2026Article
- Association of a Lifestyle Risk Index With Visceral and Subcutaneous Adipose Tissue in the German National Cohort (NAKO).Obesity (Silver Spring, Md.) · 2026Article
- From cigarettes to symptoms: the association between smoking and depression in the German National Cohort (NAKO).BMC public health · 2025Article
- Reproducibility assessment of biventricular strain derived from Long-Axis feature tracking in travelling Volunteers - A study in the Berlin research network for cardiovascular magnetic resonance (BER-CMR).The international journal of cardiovascular imaging · 2025Article
- Intermuscular adipose tissue and lean muscle mass assessed with MRI in people with chronic back pain in Germany: a retrospective observational study.The Lancet regional health. Europe · 2025Article
- Cardiac magnetic resonance imaging in the German National Cohort (NAKO): Automated segmentation of short-axis cine images and post-processing quality control.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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22 authors.
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Abstract
backgroundMagnetic resonance imaging (MRI) yields important information on the development and current status of many different diseases. Whole-body MRI was accordingly made a part of the multicenter, population-based NAKO Health Study. The present analysis concerns the feasibility of the baseline MRI examination and various aspects of quality assurance over the period 2014-2019.
methods32 252 participants in the NAKO Health Study, aged 20 to 74, who had no contraindication to MRI were invited to undergo scanning in one of five MRI study centers across Germany. The whole-body MRI scan took about one hour and consisted of sequences for the visualization of structural and functional features of the brain, musculoskeletal system, cardiovascular system, and thoracoabdominal system. A comprehensive quality-assurance assessment was carried out, with evaluation of adverse events, the completeness of the MRI protocols, the participants' subjective perceptions, and image quality.
results31 578 participants (97.9%) were successfully included in the MRI study. They reported a high level of comfort and suffered no severe adverse events (mild adverse events occurred in only four participants). Depending on the imaging sequence, the image quality was rated as excellent in 80.2% to 96.8% of cases. Quality assessment with respect to structural features of the brain revealed high consistency across study centers, as well as with regard to age- and sex-based differences in brain volume (men, 1203.81 ± 102.06 cm³; women, 1068.10 ± 86.69 cm³).
conclusionWhole-body MRI was successfully implemented in the NAKO baseline examination and was associated with high patient comfort and very good image quality. The imaging biomarkers of the brain confirmed previously observed differences based on age and sex, underscoring the feasibility of data pooling.
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