Evidence map›Paper›PMID 39158316›Full record

ArticleApplied and environmental microbiology2024

Metabolic pathway engineering of high-salinity-induced overproduction of L-proline improves high-salinity stress tolerance of an ectoine-deficient

Huynh Cong Khanh, Pulla Kaothien-Nakayama, Ziyan Zou, Hideki Nakayama

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. UsingACS ES&T engineering · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huynh Cong KhanhGraduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-8324-2763
Pulla Kaothien-NakayamaGraduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-1508-2083
Ziyan ZouGraduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-2394-0463
Hideki NakayamaGraduate School of Fisheries and Environmental Sciences, Nagasaki University, Nagasaki, Japan.ORCID 0000-0001-7590-5320

Funding

Institute for Fermentation, Osaka (IFO) LA-2022-035Japan Science and Technology Agency (JST) JPMJPF2117MEXT | Japan Society for the Promotion of Science (JSPS) 19K12400, 22K12446
6 · The paper itself

Abstract

Halophilic bacteria have adapted to survive in high-salinity environments by accumulating amino acids and their derivatives as organic osmolytes. L-Proline (Pro) is one such osmolyte that is also being used as a feed stimulant in the aquaculture industry.

Indexed as

Amino Acids, DiaminoHalomonasMetabolic EngineeringProlineBacterial ProteinsInositolMetabolic Networks and PathwaysSalinitySalt StressSalt ToleranceAmino Acids, DiaminoBacterial ProteinsectoineInositolProlineaquaculture industryHalomonas elongatahigh salinitymetabolic engineeringosmolyteproline biosynthesisself-cloning

Identifiers

PMID39158316
PMCPMC11409704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.